Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study

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dc.contributor.advisorMulder, Nicolaen_ZA
dc.contributor.advisorKaba, Mamadouen_ZA
dc.contributor.authorDube, Felix Sizween_ZA
dc.date.accessioned2016-07-25T07:12:35Z
dc.date.available2016-07-25T07:12:35Z
dc.date.issued2016en_ZA
dc.description.abstractStreptococcus pneumoniae (the pneumococcus) is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the nasopharynx by the pneumococcus is common and also serves as a reservoir for person-to-person transmission. We aimed to investigate in detail, the dynamics of pneumococcal nasopharyngeal carriage over the first year of life, in a cohort of South African children, particularly after implementation of the 13-valent pneumococcal conjugate vaccine (PCV-13). The study will further elucidate the interaction of S. pneumoniae with other respiratory pathogens and how such interactions may contribute development of severe disease.en_ZA
dc.identifier.apacitationDube, F. S. (2016). <i>Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/20649en_ZA
dc.identifier.chicagocitationDube, Felix Sizwe. <i>"Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2016. http://hdl.handle.net/11427/20649en_ZA
dc.identifier.citationDube, F. 2016. Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dube, Felix Sizwe AB - Streptococcus pneumoniae (the pneumococcus) is the most common cause of childhood pneumonia. Nasopharyngeal (NP) colonization by the pneumococcus is a necessary first step in the pathogenesis of pneumonia and yet the dynamic nature of pneumococcal colonization remains incompletely understood. In children, asymptomatic colonization of the nasopharynx by the pneumococcus is common and also serves as a reservoir for person-to-person transmission. We aimed to investigate in detail, the dynamics of pneumococcal nasopharyngeal carriage over the first year of life, in a cohort of South African children, particularly after implementation of the 13-valent pneumococcal conjugate vaccine (PCV-13). The study will further elucidate the interaction of S. pneumoniae with other respiratory pathogens and how such interactions may contribute development of severe disease. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study TI - Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study UR - http://hdl.handle.net/11427/20649 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20649
dc.identifier.vancouvercitationDube FS. Longitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort study. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20649en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Microbiologyen_ZA
dc.titleLongitudinal colonisation by Streptococcus pneumoniae and nasopharyngeal microbial interactions in health and disease: a South African birth cohort studyen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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