Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment
| dc.contributor.advisor | Shamley, Delva | |
| dc.contributor.advisor | September, Alison | |
| dc.contributor.author | Mafu, Trevor | |
| dc.date.accessioned | 2025-09-02T11:58:18Z | |
| dc.date.available | 2025-09-02T11:58:18Z | |
| dc.date.issued | 2025 | |
| dc.date.updated | 2025-09-02T11:25:28Z | |
| dc.description.abstract | Shoulder pain and disability are common sequelae of breast cancer treatment in women, with an understated negative impact on the quality of life of affected individuals and a poorly characterised aetiology. A better understanding of the aetiology of shoulder pain and disability in breast cancer survivors is urgent to develop and/or integrate effective treatments to mitigate the related reduction in quality of life– this is especially important given the increasing cancer survivorship in societies such as in South Africa where a high percentage of households are female-headed and a resource-based public healthcare system is used by the majority. Previous studies have explored treatment-related and patient-related factors that modulate risk of upper-limb impairments in breast cancer survivors, including shoulder pain and disability. However, there is a paucity of relevant studies on key genetic factors. Genetic factors within angiogenesis-related signalling and extracellular matrix (ECM) regulating pathways have been implicated in non-cancer-related studies of soft tissue conditions of the shoulder that are associated with pain and display movement dysfunction similar to that seen in breast cancer post-treatment shoulder morbidity. It is largely unknown whether or not key factors within the angiogenesis-related and ECM-regulating signalling pathways may modulate risk of shoulder pain and disability in breast cancer survivors. | |
| dc.identifier.apacitation | Mafu, T. (2025). <i>Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/41680 | en_ZA |
| dc.identifier.chicagocitation | Mafu, Trevor. <i>"Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2025. http://hdl.handle.net/11427/41680 | en_ZA |
| dc.identifier.citation | Mafu, T. 2025. Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment. . University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. http://hdl.handle.net/11427/41680 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Mafu, Trevor AB - Shoulder pain and disability are common sequelae of breast cancer treatment in women, with an understated negative impact on the quality of life of affected individuals and a poorly characterised aetiology. A better understanding of the aetiology of shoulder pain and disability in breast cancer survivors is urgent to develop and/or integrate effective treatments to mitigate the related reduction in quality of life– this is especially important given the increasing cancer survivorship in societies such as in South Africa where a high percentage of households are female-headed and a resource-based public healthcare system is used by the majority. Previous studies have explored treatment-related and patient-related factors that modulate risk of upper-limb impairments in breast cancer survivors, including shoulder pain and disability. However, there is a paucity of relevant studies on key genetic factors. Genetic factors within angiogenesis-related signalling and extracellular matrix (ECM) regulating pathways have been implicated in non-cancer-related studies of soft tissue conditions of the shoulder that are associated with pain and display movement dysfunction similar to that seen in breast cancer post-treatment shoulder morbidity. It is largely unknown whether or not key factors within the angiogenesis-related and ECM-regulating signalling pathways may modulate risk of shoulder pain and disability in breast cancer survivors. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Breast cancer KW - South Africa KW - ECM LK - https://open.uct.ac.za PB - University of Cape Town PY - 2025 T1 - Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment TI - Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment UR - http://hdl.handle.net/11427/41680 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/41680 | |
| dc.identifier.vancouvercitation | Mafu T. Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment. []. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41680 | en_ZA |
| dc.language.iso | en | |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Human Biology | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.subject | Breast cancer | |
| dc.subject | South Africa | |
| dc.subject | ECM | |
| dc.title | Exploring the association between gene sequence polymorphisms within the angiogenesis and extracellular matrix regulatory pathways and shoulder pain and disability following breast cancer treatment | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationlevel | PhD |