The role of the cytolytic mediators, granulysin and perforin, in tuberculosis

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dc.contributor.advisorRess, Stanleyen_ZA
dc.contributor.advisorShephard, Eniden_ZA
dc.contributor.authorSemple, Patricia Lynnen_ZA
dc.date.accessioned2015-02-10T13:27:27Z
dc.date.available2015-02-10T13:27:27Z
dc.date.issued2008en_ZA
dc.descriptionIncludes bibliographical references (leaves 150-175).en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.description.abstractProtective immunity against mycobacterial infection requires an effective cytolytic response, in addition to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be directly cytotoxic to extracellular Mycobacterium tuberculosis (M.tb) and, together with perforin, is cytolytic against intracellular mycobacteria. This project evaluated the role of these two cytolytic mediators in TB.en_ZA
dc.identifier.apacitationSemple, P. L. (2008). <i>The role of the cytolytic mediators, granulysin and perforin, in tuberculosis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Immunology. Retrieved from http://hdl.handle.net/11427/12403en_ZA
dc.identifier.chicagocitationSemple, Patricia Lynn. <i>"The role of the cytolytic mediators, granulysin and perforin, in tuberculosis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Immunology, 2008. http://hdl.handle.net/11427/12403en_ZA
dc.identifier.citationSemple, P. 2008. The role of the cytolytic mediators, granulysin and perforin, in tuberculosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Semple, Patricia Lynn AB - Protective immunity against mycobacterial infection requires an effective cytolytic response, in addition to an intact Type l (Th1) cytokine pathway. Natural killer (NK) cells and cytolytic T-cells (CTL) are essential components of protective immunity against tuberculosis (TB) and mediate granule-dependent killing of infected cells. Granulysin, an antimicrobial protein, and perforin, a pore-forming molecule, have been found to co-localise in the granules of these two cell types. Granulysin has been shown to be directly cytotoxic to extracellular Mycobacterium tuberculosis (M.tb) and, together with perforin, is cytolytic against intracellular mycobacteria. This project evaluated the role of these two cytolytic mediators in TB. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - The role of the cytolytic mediators, granulysin and perforin, in tuberculosis TI - The role of the cytolytic mediators, granulysin and perforin, in tuberculosis UR - http://hdl.handle.net/11427/12403 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12403
dc.identifier.vancouvercitationSemple PL. The role of the cytolytic mediators, granulysin and perforin, in tuberculosis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Immunology, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12403en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Immunologyen_ZA
dc.titleThe role of the cytolytic mediators, granulysin and perforin, in tuberculosisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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