Safety of long-term isoniazid preventive therapy in children with HIV

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dc.contributor.advisorMyer, Landonen_ZA
dc.contributor.advisorZar, Heatheren_ZA
dc.contributor.authorLe Roux, Stanzi Mariaen_ZA
dc.date.accessioned2014-08-05T13:05:08Z
dc.date.available2014-08-05T13:05:08Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractTuberculosis (TB) and HIV co-infection is association with significant morbidity and mortality, especially in young children. Prevention of tuberculosis in children with HIV is a global health priority and is best achieved through a combination of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT). Current WHO guidelines recommend 6 months of IPT for all HIV-infected children older than 1 year without TB disease; up to 3 years is recommended in high TB prevalence areas. Although both ART and IPT can cause liver injury, data on the safety of IPT in HIV-infected children accessing ART is limited, and no published data exist on the hepatotoxicity risk of prolonged IPT. This thesis aims to address these knowledge gaps.en_ZA
dc.identifier.apacitationLe Roux, S. M. (2014). <i>Safety of long-term isoniazid preventive therapy in children with HIV</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/6023en_ZA
dc.identifier.chicagocitationLe Roux, Stanzi Maria. <i>"Safety of long-term isoniazid preventive therapy in children with HIV."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2014. http://hdl.handle.net/11427/6023en_ZA
dc.identifier.citationLe Roux, S. 2014. Safety of long-term isoniazid preventive therapy in children with HIV. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Le Roux, Stanzi Maria AB - Tuberculosis (TB) and HIV co-infection is association with significant morbidity and mortality, especially in young children. Prevention of tuberculosis in children with HIV is a global health priority and is best achieved through a combination of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT). Current WHO guidelines recommend 6 months of IPT for all HIV-infected children older than 1 year without TB disease; up to 3 years is recommended in high TB prevalence areas. Although both ART and IPT can cause liver injury, data on the safety of IPT in HIV-infected children accessing ART is limited, and no published data exist on the hepatotoxicity risk of prolonged IPT. This thesis aims to address these knowledge gaps. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Safety of long-term isoniazid preventive therapy in children with HIV TI - Safety of long-term isoniazid preventive therapy in children with HIV UR - http://hdl.handle.net/11427/6023 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6023
dc.identifier.vancouvercitationLe Roux SM. Safety of long-term isoniazid preventive therapy in children with HIV. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6023en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Healthen_ZA
dc.titleSafety of long-term isoniazid preventive therapy in children with HIVen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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