Safety of long-term isoniazid preventive therapy in children with HIV

Master Thesis

2014

Permanent link to this Item
http://hdl.handle.net/11427/6023
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thesis_hsf_2014_leroux_s (1).pdf (3.5 MB)
Authors
Le Roux, Stanzi Maria
Supervisors
Myer, Landon
Zar, Heather
Journal Title
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Publisher
Publisher

University of Cape Town

Department
Department of Public Health and Family Medicine
Faculty
Faculty of Health Sciences
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Abstract
Tuberculosis (TB) and HIV co-infection is association with significant morbidity and mortality, especially in young children. Prevention of tuberculosis in children with HIV is a global health priority and is best achieved through a combination of antiretroviral therapy (ART) and isoniazid preventive therapy (IPT). Current WHO guidelines recommend 6 months of IPT for all HIV-infected children older than 1 year without TB disease; up to 3 years is recommended in high TB prevalence areas. Although both ART and IPT can cause liver injury, data on the safety of IPT in HIV-infected children accessing ART is limited, and no published data exist on the hepatotoxicity risk of prolonged IPT. This thesis aims to address these knowledge gaps.
Description

Includes bibliographical references.

Keywords
Public Health

Reference:

Le Roux, S. 2014. Safety of long-term isoniazid preventive therapy in children with HIV. University of Cape Town.

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