Relationships between psychosocial stress, cortisol, apolipoprotein є4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults

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dc.contributor.advisorThomas, Kevinen_ZA
dc.contributor.authorJames, Katharine Annen_ZA
dc.date.accessioned2015-01-08T20:02:22Z
dc.date.available2015-01-08T20:02:22Z
dc.date.issued2013en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractMany factors contribute to age-related changes in cognitive functioning. There is no single defined profile of factors that is clearly associated with the presence, or rate of progression, of cognitive changes in older adults. Stress, both psychosocial and physiological, may play a role. Aims: The general aim of this study was to explore the relationships between cognitive functioning and cognitive decline, on the one hand, and psychosocial and physiological stress, as well as a range of sociodemographic, psychosocial and physiological factors, on the other, in older adults with a range of cognitive function including healthy and impaired. Methods: Both cross-sectional (Study 1) and longitudinal (Study 2) designs addressed these aims. Study 1 examined the contribution of stress and sociodemographic, psychosocial, and physiological factors to cognition. Participants were 69 cognitively healthy older adults and 65 possible or probable Alzheimer’s disease (AD) patients. They were all over the age of 60 and resided in the greater Cape Town metropolitan region of South Africa. Cognitive functioning was assessed using a battery of neuropsychological tests. Salivary cortisol levels, apolipoprotein E (APOE) genotype, and plasma beta-amyloid levels were determined at baseline.en_ZA
dc.identifier.apacitationJames, K. A. (2013). <i>Relationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults</i>. (Thesis). University of Cape Town ,Faculty of Humanities ,Department of Psychology. Retrieved from http://hdl.handle.net/11427/11796en_ZA
dc.identifier.chicagocitationJames, Katharine Ann. <i>"Relationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults."</i> Thesis., University of Cape Town ,Faculty of Humanities ,Department of Psychology, 2013. http://hdl.handle.net/11427/11796en_ZA
dc.identifier.citationJames, K. 2013. Relationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - James, Katharine Ann AB - Many factors contribute to age-related changes in cognitive functioning. There is no single defined profile of factors that is clearly associated with the presence, or rate of progression, of cognitive changes in older adults. Stress, both psychosocial and physiological, may play a role. Aims: The general aim of this study was to explore the relationships between cognitive functioning and cognitive decline, on the one hand, and psychosocial and physiological stress, as well as a range of sociodemographic, psychosocial and physiological factors, on the other, in older adults with a range of cognitive function including healthy and impaired. Methods: Both cross-sectional (Study 1) and longitudinal (Study 2) designs addressed these aims. Study 1 examined the contribution of stress and sociodemographic, psychosocial, and physiological factors to cognition. Participants were 69 cognitively healthy older adults and 65 possible or probable Alzheimer’s disease (AD) patients. They were all over the age of 60 and resided in the greater Cape Town metropolitan region of South Africa. Cognitive functioning was assessed using a battery of neuropsychological tests. Salivary cortisol levels, apolipoprotein E (APOE) genotype, and plasma beta-amyloid levels were determined at baseline. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Relationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults TI - Relationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults UR - http://hdl.handle.net/11427/11796 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/11796
dc.identifier.vancouvercitationJames KA. Relationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adults. [Thesis]. University of Cape Town ,Faculty of Humanities ,Department of Psychology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11796en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Psychologyen_ZA
dc.publisher.facultyFaculty of Humanitiesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPhilosophyen_ZA
dc.titleRelationships between psychosocial stress, cortisol, apolipoprotein &#1108;4, beta-amyloid, hippocampal volumes and Alzheimer's disease in a sample of South African older adultsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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