The characterization of adaptor protein homologues in Plasmodium falciparum

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dc.contributor.advisorHoppe, Heinrich Cen_ZA
dc.contributor.authorMeredith, Sandra Allisonen_ZA
dc.date.accessioned2014-07-28T18:19:16Z
dc.date.available2014-07-28T18:19:16Z
dc.date.issued2009en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (leaves 148-171).
dc.description.abstractPlasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains.en_ZA
dc.identifier.apacitationMeredith, S. A. (2009). <i>The characterization of adaptor protein homologues in Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology. Retrieved from http://hdl.handle.net/11427/3291en_ZA
dc.identifier.chicagocitationMeredith, Sandra Allison. <i>"The characterization of adaptor protein homologues in Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009. http://hdl.handle.net/11427/3291en_ZA
dc.identifier.citationMeredith, S. 2009. The characterization of adaptor protein homologues in Plasmodium falciparum. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Meredith, Sandra Allison AB - Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets. Components of the endocytic and secretory pathway in asexual stage parasites are attractive targets because they play a fundamental role in the normal processes of parasite metabolism. Adaptor protein complexes are components of protein coats that associate with transport vesicles of the endocytic and secretory pathways in mammalian cells. Homologues of several adaptor protein subunits are encoded by the parasite genome. The presence of these genes suggests that the parasite experiences clathrin-mediated transport processes. This study reports the cloning and characterization of selected malarial homologues of these adaptor proteins, namely three medium (μ) chain adaptin homologues and two sigma (σ) chains. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - The characterization of adaptor protein homologues in Plasmodium falciparum TI - The characterization of adaptor protein homologues in Plasmodium falciparum UR - http://hdl.handle.net/11427/3291 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3291
dc.identifier.vancouvercitationMeredith SA. The characterization of adaptor protein homologues in Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Clinical Pharmacology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3291en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPharmacologyen_ZA
dc.titleThe characterization of adaptor protein homologues in Plasmodium falciparumen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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