Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity
| dc.contributor.advisor | Chibale, Kelly | |
| dc.contributor.advisor | Wicht, Kathryn | |
| dc.contributor.advisor | Woodland, John | |
| dc.contributor.advisor | Egan, Timothy | |
| dc.contributor.author | Ishmail, Fatima-Zahra | |
| dc.date.accessioned | 2025-09-18T10:30:10Z | |
| dc.date.available | 2025-09-18T10:30:10Z | |
| dc.date.issued | 2025 | |
| dc.date.updated | 2025-08-18T13:31:41Z | |
| dc.description.abstract | Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics. With the reported development of partial resistance to the current front-line artemisinin-based combination therapies, there is an increased risk of malaria morbidity and mortality as limited replacement treatments are currently available. For that reason, it is essential to invest in the discovery of compounds with novel mechanisms of action (MoA), dual-stage activity, and with immutable targets. Until now, drug discovery has typically focused on the development of antimalarials that are entirely organic in composition. This has left the field of inorganic medicinal chemistry and transition metal-based chemotherapeutics underexplored and underrepresented. | |
| dc.identifier.apacitation | Ishmail, F. (2025). <i>Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity</i>. (). Universiy of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/41857 | en_ZA |
| dc.identifier.chicagocitation | Ishmail, Fatima-Zahra. <i>"Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity."</i> ., Universiy of Cape Town ,Faculty of Science ,Department of Chemistry, 2025. http://hdl.handle.net/11427/41857 | en_ZA |
| dc.identifier.citation | Ishmail, F. 2025. Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity. . Universiy of Cape Town ,Faculty of Science ,Department of Chemistry. http://hdl.handle.net/11427/41857 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Ishmail, Fatima-Zahra AB - Malaria remains one of the largest parasitic disease burdens worldwide, with the vast majority of that burden occurring on the African continent. The ongoing high number of malaria cases and deaths is in part attributable to the emergence and spread of resistance to most clinical chemotherapeutics. With the reported development of partial resistance to the current front-line artemisinin-based combination therapies, there is an increased risk of malaria morbidity and mortality as limited replacement treatments are currently available. For that reason, it is essential to invest in the discovery of compounds with novel mechanisms of action (MoA), dual-stage activity, and with immutable targets. Until now, drug discovery has typically focused on the development of antimalarials that are entirely organic in composition. This has left the field of inorganic medicinal chemistry and transition metal-based chemotherapeutics underexplored and underrepresented. DA - 2025 DB - OpenUCT DP - University of Cape Town KW - Malaria KW - parasitic disease KW - African LK - https://open.uct.ac.za PB - Universiy of Cape Town PY - 2025 T1 - Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity TI - Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity UR - http://hdl.handle.net/11427/41857 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/41857 | |
| dc.identifier.vancouvercitation | Ishmail F. Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity. []. Universiy of Cape Town ,Faculty of Science ,Department of Chemistry, 2025 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41857 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Chemistry | |
| dc.publisher.faculty | Faculty of Science | |
| dc.publisher.institution | Universiy of Cape Town | |
| dc.subject | Malaria | |
| dc.subject | parasitic disease | |
| dc.subject | African | |
| dc.title | Probing the mechanisms of action and resistance of mixed-ligand platinum(II) complexes with dual-stage antiplasmodium activity | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Doctoral | |
| dc.type.qualificationlevel | PhD |