Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation

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dc.contributor.advisorRodgers, Allenen_ZA
dc.contributor.advisorSturrock, Edward Den_ZA
dc.contributor.authorMabizela, Nontobekoen_ZA
dc.date.accessioned2015-09-15T10:33:50Z
dc.date.available2015-09-15T10:33:50Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves [184]-205).en_ZA
dc.description.abstractApproximately 12 % of males in the Western world are likely to suffer at least one kidney stone in their life. The incidence of kidney stone disease in South Africa is similar in white males; however stone occurrence in the South African black population is extremely rare. The difference between the incidences of kidney stones in the black and white populations in South Africa is unexplained. In general, the role of several urinary proteins in the pathogenesis of this disease has been established. Bikunin is an example. The primary aim of this study was to isolate bikunin from the urine of healthy black and white male subjects and to investigate whether the protein from the black group is a more powerful inhibitor of CaOx crystallization than that from the stone prone white group.en_ZA
dc.identifier.apacitationMabizela, N. (2006). <i>Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/14033en_ZA
dc.identifier.chicagocitationMabizela, Nontobeko. <i>"Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2006. http://hdl.handle.net/11427/14033en_ZA
dc.identifier.citationMabizela, N. 2006. Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mabizela, Nontobeko AB - Approximately 12 % of males in the Western world are likely to suffer at least one kidney stone in their life. The incidence of kidney stone disease in South Africa is similar in white males; however stone occurrence in the South African black population is extremely rare. The difference between the incidences of kidney stones in the black and white populations in South Africa is unexplained. In general, the role of several urinary proteins in the pathogenesis of this disease has been established. Bikunin is an example. The primary aim of this study was to isolate bikunin from the urine of healthy black and white male subjects and to investigate whether the protein from the black group is a more powerful inhibitor of CaOx crystallization than that from the stone prone white group. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation TI - Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation UR - http://hdl.handle.net/11427/14033 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14033
dc.identifier.vancouvercitationMabizela N. Characterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formation. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/14033en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleCharacterization of the physiochemical and biochemical properties of the urinary protein bikunin in South African black and white subjects with respect to calcium oxalate kidney stone formationen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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