Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes

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dc.contributor.advisorSmith, Gregory Sen_ZA
dc.contributor.authorBurgoyne, Andrew Ren_ZA
dc.date.accessioned2016-07-11T13:53:39Z
dc.date.available2016-07-11T13:53:39Z
dc.date.issued2016en_ZA
dc.description.abstractOver the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride.en_ZA
dc.identifier.apacitationBurgoyne, A. R. (2016). <i>Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/20303en_ZA
dc.identifier.chicagocitationBurgoyne, Andrew R. <i>"Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2016. http://hdl.handle.net/11427/20303en_ZA
dc.identifier.citationBurgoyne, A. 2016. Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Burgoyne, Andrew R AB - Over the past few decades metals in medicine have played to play a significant role, especially after the discovery of the anticancer properties of cisplatin. However, acquired and intrinsic resistance, toxicity and a host of side-effects have encouraged the research for new metal based anticancer agents. Organometallic complexes have proved to be successful anticancer agents and several have commenced clinical trials. The aim of this study was to prepare and characterize trinuclear platinum group organometallic complexes and investigate their in vitro activity. The first series of ester containing complexes were prepared. The ligands were generated by the preparation of Schiff base ligands obtained from the condensation of 4-aminophenylmethanol and either benzaldehyde, 2-pyridinecarboxaldehyde or salicylaldehyde. Trimeric ester ligands were prepared from these monomeric ligands by reaction with trimesoyl chloride. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes TI - Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes UR - http://hdl.handle.net/11427/20303 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20303
dc.identifier.vancouvercitationBurgoyne AR. Development, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexes. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20303en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleDevelopment, synthesis and anticancer evaluation of trinuclear Platinum Group Metal organometallic complexesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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