The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene

Simple item page
dc.contributor.advisorParker, M Iqbalen_ZA
dc.contributor.authorNdlovu, Matladi Nen_ZA
dc.date.accessioned2014-07-28T14:55:50Z
dc.date.available2014-07-28T14:55:50Z
dc.date.issued2002en_ZA
dc.descriptionBibliography leaves 70-97.
dc.description.abstractType I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression.en_ZA
dc.identifier.apacitationNdlovu, M. N. (2002). <i>The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3144en_ZA
dc.identifier.chicagocitationNdlovu, Matladi N. <i>"The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2002. http://hdl.handle.net/11427/3144en_ZA
dc.identifier.citationNdlovu, M. 2002. The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Ndlovu, Matladi N AB - Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression. DA - 2002 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2002 T1 - The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene TI - The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene UR - http://hdl.handle.net/11427/3144 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3144
dc.identifier.vancouvercitationNdlovu MN. The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2002 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3144en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleThe role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) geneen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2002_ndlovu_mn (1).pdf
Size:
10.45 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters