The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
Master Thesis
2002
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University of Cape Town
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Abstract
Type I collagen is the most abundant collagen molecule in vertebrate connective tissue and it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is inversely correlated with transcriptional activity and plays a critical role in differential gene expression.
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Bibliography leaves 70-97.
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Ndlovu, M. 2002. The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene. University of Cape Town.