Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix

Simple item page
dc.contributor.advisorAbratt, Valerie Roseen_ZA
dc.contributor.authorGalvao, Bruna Patricia Gomes de Vasconcelosen_ZA
dc.date.accessioned2014-12-30T06:42:29Z
dc.date.available2014-12-30T06:42:29Z
dc.date.issued2010en_ZA
dc.descriptionIncludes bibliographical references (p. 116-126).en_ZA
dc.description.abstractBacteroides fragilis is an opportunistic pathogen which can cause life threatening infections in humans and animals. The increasing incidence of antibiotic resistance by the bacterium has prompted the search for novel therapeutic targets. The idea of antivirulence over antimicrobial drug development is becoming increasingly popular and invites detailed research into the virulence factors of target pathogens. The ability to adhere to, and degrade components of the extracellular matrix, such as collagen, is critical in bacterial colonisation and host cell invasion. The aim of this dissertation was to specifically identify the collagen type I adhesins and proteases in the common research strain, B. fragilis 638R, as well as in 23 clinical isolates from Groote Schuur Hospital (GSH), Cape Town.en_ZA
dc.identifier.apacitationGalvao, B. P. G. d. V. (2010). <i>Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/10522en_ZA
dc.identifier.chicagocitationGalvao, Bruna Patricia Gomes de Vasconcelos. <i>"Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2010. http://hdl.handle.net/11427/10522en_ZA
dc.identifier.citationGalvao, B. 2010. Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Galvao, Bruna Patricia Gomes de Vasconcelos AB - Bacteroides fragilis is an opportunistic pathogen which can cause life threatening infections in humans and animals. The increasing incidence of antibiotic resistance by the bacterium has prompted the search for novel therapeutic targets. The idea of antivirulence over antimicrobial drug development is becoming increasingly popular and invites detailed research into the virulence factors of target pathogens. The ability to adhere to, and degrade components of the extracellular matrix, such as collagen, is critical in bacterial colonisation and host cell invasion. The aim of this dissertation was to specifically identify the collagen type I adhesins and proteases in the common research strain, B. fragilis 638R, as well as in 23 clinical isolates from Groote Schuur Hospital (GSH), Cape Town. DA - 2010 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2010 T1 - Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix TI - Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix UR - http://hdl.handle.net/11427/10522 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10522
dc.identifier.vancouvercitationGalvao BPGdV. Bacteriodes fragilis interactions with the collagen type I component of the host extracellular matrix. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2010 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10522en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleBacteriodes fragilis interactions with the collagen type I component of the host extracellular matrixen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2010_galvao_b.pdf
Size:
1.76 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
PhD / Doctoral