The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation

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dc.contributor.advisorvan der Spuy, Zephne Margareten_ZA
dc.contributor.advisorKatz, Ariehen_ZA
dc.contributor.advisorMillar, Roberten_ZA
dc.contributor.authorMatjila, Mushi Johannesen_ZA
dc.date.accessioned2015-12-04T18:02:21Z
dc.date.available2015-12-04T18:02:21Z
dc.date.issued2015en_ZA
dc.description.abstractPoor invasion of trophoblast cells in early pregnancy has been associated with preeclampsia and intrauterine growth restriction as well as other adverse pregnancy outcomes such as miscarriage, preterm birth and intrauterine death. Hypertensive disorders of pregnancy, including pre-eclampsia are one of the leading causes of maternal mortality in South Africa (Third report on Confidential Enquiries into Maternal Deaths in South Africa (2002-2004)) and the rest of the world. The currently accepted mechanism underlying the development of preeclampsia implicates poor trophoblast invasion and inadequate transformation of the maternal spiral arteries. Despite extensive research in this area, the control of trophoblast invasion and early placental development remains poorly understood. A whole host of factors such as oxygen tension, activation of matrix metalloproteinases (MMPs), angiogenic factors (VEGF-A) and immunological factors such as TNF alpha, interleukins and TGFβ have been shown to be involved in the control of trophoblast invasion. Our knowledge of the molecular details of pregnancy is unfortunately limited to in-vitro experiments and animal studies. Recently kisspeptins and their cognate receptor GPR-54 originally involved in tumour metastasis suppression and regulation of puberty, have been implicated in the inhibition of trophoblast invasion. Expression levels of kisspeptin and its receptor in trophoblast cells are highest in the first trimester, when control of trophoblast invasion is critical, and lower towards term.en_ZA
dc.identifier.apacitationMatjila, M. J. (2015). <i>The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Obstetrics and Gynaecology. Retrieved from http://hdl.handle.net/11427/15578en_ZA
dc.identifier.chicagocitationMatjila, Mushi Johannes. <i>"The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Obstetrics and Gynaecology, 2015. http://hdl.handle.net/11427/15578en_ZA
dc.identifier.citationMatjila, M. 2015. The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Matjila, Mushi Johannes AB - Poor invasion of trophoblast cells in early pregnancy has been associated with preeclampsia and intrauterine growth restriction as well as other adverse pregnancy outcomes such as miscarriage, preterm birth and intrauterine death. Hypertensive disorders of pregnancy, including pre-eclampsia are one of the leading causes of maternal mortality in South Africa (Third report on Confidential Enquiries into Maternal Deaths in South Africa (2002-2004)) and the rest of the world. The currently accepted mechanism underlying the development of preeclampsia implicates poor trophoblast invasion and inadequate transformation of the maternal spiral arteries. Despite extensive research in this area, the control of trophoblast invasion and early placental development remains poorly understood. A whole host of factors such as oxygen tension, activation of matrix metalloproteinases (MMPs), angiogenic factors (VEGF-A) and immunological factors such as TNF alpha, interleukins and TGFβ have been shown to be involved in the control of trophoblast invasion. Our knowledge of the molecular details of pregnancy is unfortunately limited to in-vitro experiments and animal studies. Recently kisspeptins and their cognate receptor GPR-54 originally involved in tumour metastasis suppression and regulation of puberty, have been implicated in the inhibition of trophoblast invasion. Expression levels of kisspeptin and its receptor in trophoblast cells are highest in the first trimester, when control of trophoblast invasion is critical, and lower towards term. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation TI - The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation UR - http://hdl.handle.net/11427/15578 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15578
dc.identifier.vancouvercitationMatjila MJ. The role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentation. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Obstetrics and Gynaecology, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/15578en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Obstetrics and Gynaecologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherObstetrics and Gynaecologyen_ZA
dc.titleThe role of kisspeptin and its cognate receptor GPR54 in normal and abnormal placentationen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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