The role of viral sequences in genetic aberrations and malignant transformation

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dc.contributor.advisorParker, Iqbalen_ZA
dc.contributor.authorMwapagha, Lamech Malaghoen_ZA
dc.date.accessioned2015-05-26T14:14:50Z
dc.date.available2015-05-26T14:14:50Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractCancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in only 3% of normal healthy asymptomatic individuals, implicating it as a possible risk factor. The aim of this study was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma. Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in only 3% of normal healthy asymptomatic individuals, implicating it as a possible risk factor. The aim of this study was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma.en_ZA
dc.identifier.apacitationMwapagha, L. M. (2014). <i>The role of viral sequences in genetic aberrations and malignant transformation</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/12870en_ZA
dc.identifier.chicagocitationMwapagha, Lamech Malagho. <i>"The role of viral sequences in genetic aberrations and malignant transformation."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2014. http://hdl.handle.net/11427/12870en_ZA
dc.identifier.citationMwapagha, L. 2014. The role of viral sequences in genetic aberrations and malignant transformation. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mwapagha, Lamech Malagho AB - Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in only 3% of normal healthy asymptomatic individuals, implicating it as a possible risk factor. The aim of this study was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma. Cancer is a leading cause of death worldwide and viral infections such as HBV/HCV and HPV have been known to be responsible for up to 20% of cancers in low- and middle-income countries. Approximately 500,000 of these deaths are due to oesophageal squamous cell carcinoma (OSSC) alone, one of the major cancers in Eastern and Southern Africa, Latin America and Asia. Previous studies have shown HPV DNA to be integrated in nearly 40% of oesophageal tumours whereas it was present in only 3% of normal healthy asymptomatic individuals, implicating it as a possible risk factor. The aim of this study was to compare the roles and effects of the E6 gene from the low risk HPV11 and high risk HPV18 on the cellular gene expression profile in order to identify genes required for the initiation of cellular transformation and also to identify genomic alterations associated with oesophageal squamous cell carcinoma. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - The role of viral sequences in genetic aberrations and malignant transformation TI - The role of viral sequences in genetic aberrations and malignant transformation UR - http://hdl.handle.net/11427/12870 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12870
dc.identifier.vancouvercitationMwapagha LM. The role of viral sequences in genetic aberrations and malignant transformation. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12870en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleThe role of viral sequences in genetic aberrations and malignant transformationen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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