African mole rats as models for regressive evolution of the eye

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dc.contributor.advisorKidson, Sue Hen_ZA
dc.contributor.authorNikitina, Natalyaen_ZA
dc.date.accessioned2014-07-28T18:14:06Z
dc.date.available2014-07-28T18:14:06Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves 152-166).
dc.description.abstractDarkness-adapted mammals with reduced eyes can serve as valuable models for the study of regressive evolution, as well as for research into the genetic and developmental processes underlying the "degeneration" of the eye. The aim of this work was to characterize two African mole rate species (Heterocephalus glaber and Bathyergus suillus) and explore their potential use as novel models for evolutionary developmental eye research. To this end, this histological structure of the adult eye, the development of the eye and the expression of several molecular markers were investigated. The important abnormal features noted were: the abnormal shape and nuclear distribution in the lens, the extremely large ciliary body and delay in the formation of the anterior chamber compared to other ocular structures.en_ZA
dc.identifier.apacitationNikitina, N. (2006). <i>African mole rats as models for regressive evolution of the eye</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3187en_ZA
dc.identifier.chicagocitationNikitina, Natalya. <i>"African mole rats as models for regressive evolution of the eye."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006. http://hdl.handle.net/11427/3187en_ZA
dc.identifier.citationNikitina, N. 2006. African mole rats as models for regressive evolution of the eye. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Nikitina, Natalya AB - Darkness-adapted mammals with reduced eyes can serve as valuable models for the study of regressive evolution, as well as for research into the genetic and developmental processes underlying the "degeneration" of the eye. The aim of this work was to characterize two African mole rate species (Heterocephalus glaber and Bathyergus suillus) and explore their potential use as novel models for evolutionary developmental eye research. To this end, this histological structure of the adult eye, the development of the eye and the expression of several molecular markers were investigated. The important abnormal features noted were: the abnormal shape and nuclear distribution in the lens, the extremely large ciliary body and delay in the formation of the anterior chamber compared to other ocular structures. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - African mole rats as models for regressive evolution of the eye TI - African mole rats as models for regressive evolution of the eye UR - http://hdl.handle.net/11427/3187 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3187
dc.identifier.vancouvercitationNikitina N. African mole rats as models for regressive evolution of the eye. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3187en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titleAfrican mole rats as models for regressive evolution of the eyeen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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