Computational biomechanics in the remodelling rat heart post myocardial infarction

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dc.contributor.advisorFranz , Thomasen_ZA
dc.contributor.advisorDavies, Neilen_ZA
dc.contributor.advisorDubuis, Lauraen_ZA
dc.contributor.authorMasithulela, Fulufhelo Jamesen_ZA
dc.date.accessioned2016-07-21T11:01:14Z
dc.date.available2016-07-21T11:01:14Z
dc.date.issued2016en_ZA
dc.description.abstractCardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction.en_ZA
dc.identifier.apacitationMasithulela, F. J. (2016). <i>Computational biomechanics in the remodelling rat heart post myocardial infarction</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology. Retrieved from http://hdl.handle.net/11427/20555en_ZA
dc.identifier.chicagocitationMasithulela, Fulufhelo James. <i>"Computational biomechanics in the remodelling rat heart post myocardial infarction."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2016. http://hdl.handle.net/11427/20555en_ZA
dc.identifier.citationMasithulela, F. 2016. Computational biomechanics in the remodelling rat heart post myocardial infarction. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Masithulela, Fulufhelo James AB - Cardiovascular diseases account for one third of all deaths worldwide, more than 33% of which are related to ischemic heart disease, including myocardial infarction (MI). This thesis seeks to provide insight and understanding of mechanisms during different stages of MI by utilizing finite element (FE) modelling. Three-dimensional biventricular rat heart geometries were developed from cardiac magnetic resonance images of a healthy heart and a heart with left ventricular (LV) infarction two weeks and four weeks after infarct induction. From these geometries, FE models were established. To represent the myocardium, a structure-based constitutive model and a rule-based myofibre distribution were developed to simulate both passive mechanics and active contraction. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Computational biomechanics in the remodelling rat heart post myocardial infarction TI - Computational biomechanics in the remodelling rat heart post myocardial infarction UR - http://hdl.handle.net/11427/20555 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20555
dc.identifier.vancouvercitationMasithulela FJ. Computational biomechanics in the remodelling rat heart post myocardial infarction. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Cardiology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20555en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherCardiovascular Biomechanicsen_ZA
dc.titleComputational biomechanics in the remodelling rat heart post myocardial infarctionen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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