Continuous low dose rate irradiation of the rat brain

dc.contributor.advisorBlekkenhorst, Gerhardus Hendrikusen_ZA
dc.contributor.authorMadhoo, Jiteshen_ZA
dc.date.accessioned2018-01-09T14:12:07Z
dc.date.available2018-01-09T14:12:07Z
dc.date.issued1999en_ZA
dc.description.abstractThe reported median survival time for patients who are diagnosed with high grade astrocytomas and who undergo postoperative radiotherapy is of the order of 24 to 40 weeks. The course of radiotherapy administered to these patients takes up a considerable portion of their expected survival time. Therefore, any means of reducing the treatment time may contribute to an enhanced quality of life for these patients. A potentially useful method for the reduction of the treatment time may be achieved with the use of continuous low dose rate external beam radiotherapy, where the treatment is administered over a 12 to 24 hour period. A relationship between fractionated and continuous low dose rate irradiation has been reported for skin, however, no such relationship has been reported for the brain. Low dose rate protocols that are equivalent in effect to fractionated (conventional) protocols can be derived using the linear quadratic theory, provided that quantitative radiobiological data for normal tissue (brain) is known. Thus, the aim of the current study is to test the radiation tolerance of the rat brain to low dose rate and fractionated radiation in order to establish the values for the parameters of the linear quadratic model.en_ZA
dc.identifier.apacitationMadhoo, J. (1999). <i>Continuous low dose rate irradiation of the rat brain</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Radiation Oncology. Retrieved from http://hdl.handle.net/11427/26785en_ZA
dc.identifier.chicagocitationMadhoo, Jitesh. <i>"Continuous low dose rate irradiation of the rat brain."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Radiation Oncology, 1999. http://hdl.handle.net/11427/26785en_ZA
dc.identifier.citationMadhoo, J. 1999. Continuous low dose rate irradiation of the rat brain. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Madhoo, Jitesh AB - The reported median survival time for patients who are diagnosed with high grade astrocytomas and who undergo postoperative radiotherapy is of the order of 24 to 40 weeks. The course of radiotherapy administered to these patients takes up a considerable portion of their expected survival time. Therefore, any means of reducing the treatment time may contribute to an enhanced quality of life for these patients. A potentially useful method for the reduction of the treatment time may be achieved with the use of continuous low dose rate external beam radiotherapy, where the treatment is administered over a 12 to 24 hour period. A relationship between fractionated and continuous low dose rate irradiation has been reported for skin, however, no such relationship has been reported for the brain. Low dose rate protocols that are equivalent in effect to fractionated (conventional) protocols can be derived using the linear quadratic theory, provided that quantitative radiobiological data for normal tissue (brain) is known. Thus, the aim of the current study is to test the radiation tolerance of the rat brain to low dose rate and fractionated radiation in order to establish the values for the parameters of the linear quadratic model. DA - 1999 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1999 T1 - Continuous low dose rate irradiation of the rat brain TI - Continuous low dose rate irradiation of the rat brain UR - http://hdl.handle.net/11427/26785 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26785
dc.identifier.vancouvercitationMadhoo J. Continuous low dose rate irradiation of the rat brain. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Radiation Oncology, 1999 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/26785en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Radiation Oncologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherRadiation Oncologyen_ZA
dc.titleContinuous low dose rate irradiation of the rat brainen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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