The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome

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dc.contributor.advisorMeintjes, Graeme
dc.contributor.advisorShey Muki
dc.contributor.authorStek, Cari
dc.date.accessioned2025-08-08T11:25:34Z
dc.date.available2025-08-08T11:25:34Z
dc.date.issued2022
dc.date.updated2025-08-08T11:23:51Z
dc.description.abstractIn this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events.
dc.identifier.apacitationStek, C. (2022). <i>The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome</i>. (). ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/41559en_ZA
dc.identifier.chicagocitationStek, Cari. <i>"The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome."</i> ., ,Faculty of Health Sciences ,Department of Medicine, 2022. http://hdl.handle.net/11427/41559en_ZA
dc.identifier.citationStek, C. 2022. The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome. . ,Faculty of Health Sciences ,Department of Medicine. http://hdl.handle.net/11427/41559en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Stek, Cari AB - In this thesis, I assess the effect of prednisone on immunopathology and pulmonary function in HIV-associated tuberculosis and tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). I do this using data collected during the PredART trial. This randomized, double-blind, placebo-controlled trial showed that a 28-day course of prophylactic prednisone in adult patients identified as being at high risk for paradoxical TB-IRIS reduced the incidence of paradoxical TB-IRIS by 30%, without an excess of adverse events. DA - 2022 DB - OpenUCT DP - University of Cape Town KW - lung function LK - https://open.uct.ac.za PY - 2022 T1 - The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome TI - The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome UR - http://hdl.handle.net/11427/41559 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/41559
dc.identifier.vancouvercitationStek C. The immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome. []. ,Faculty of Health Sciences ,Department of Medicine, 2022 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41559en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.subjectlung function
dc.titleThe immunomodulatory role of prednisone in patients with HIV-associated tuberculosis and assessment of its impact on lung function outcome
dc.typeThesis / Dissertation
dc.type.qualificationlevelDoctoral
dc.type.qualificationlevelPhD
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