Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease

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dc.contributor.advisorBateman, Eric Den_ZA
dc.contributor.authorAllwood, Brian Williamen_ZA
dc.date.accessioned2015-05-04T07:07:44Z
dc.date.available2015-05-04T07:07:44Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractEpidemiological studies in populations with a high burden of pulmonary tuberculosis (PTB), including the Burden of Obstructive Lung Disease (BOLD) survey performed in Cape Town, South Africa in 2005, have suggested an association between PTB and the development of chronic airflow obstruction (CAO). The nature of this association and mechanisms responsible for CAO has not been previously studied, but likely includes: airway narrowing (from bronchiolitis, bronchiectasis or persistent low-grade inflammation associated with healed PTB); and reduced lung elastic recoil from coexistent emphysema. The present study investigated the structure and function of the lung in subjects with tuberculosis-associated obstructive pulmonary disease (TOPD) identified in BOLD 2005, and aspects of its natural history and response to treatment. It also examined the diagnostic performance of the standardised and internationally accepted BOLD method for estimating the prevalence of COPD in community-based surveys, with specific reference to misdiagnosis that might lead to overestimates of prevalence.en_ZA
dc.identifier.apacitationAllwood, B. W. (2014). <i>Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/12715en_ZA
dc.identifier.chicagocitationAllwood, Brian William. <i>"Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2014. http://hdl.handle.net/11427/12715en_ZA
dc.identifier.citationAllwood, B. 2014. Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Allwood, Brian William AB - Epidemiological studies in populations with a high burden of pulmonary tuberculosis (PTB), including the Burden of Obstructive Lung Disease (BOLD) survey performed in Cape Town, South Africa in 2005, have suggested an association between PTB and the development of chronic airflow obstruction (CAO). The nature of this association and mechanisms responsible for CAO has not been previously studied, but likely includes: airway narrowing (from bronchiolitis, bronchiectasis or persistent low-grade inflammation associated with healed PTB); and reduced lung elastic recoil from coexistent emphysema. The present study investigated the structure and function of the lung in subjects with tuberculosis-associated obstructive pulmonary disease (TOPD) identified in BOLD 2005, and aspects of its natural history and response to treatment. It also examined the diagnostic performance of the standardised and internationally accepted BOLD method for estimating the prevalence of COPD in community-based surveys, with specific reference to misdiagnosis that might lead to overestimates of prevalence. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease TI - Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease UR - http://hdl.handle.net/11427/12715 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12715
dc.identifier.vancouvercitationAllwood BW. Tuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary disease. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12715en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.titleTuberculosis-associated obstructive pulmonary disease: a clinical, radiological and pathophysiological study of the contribution of previous pulmonary tuberculosis in a community-based study of chronic obstructive pulmonary diseaseen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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