Inclusion of alkylparabens in cyclodextrins

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dc.contributor.advisorCaira, Mino Ren_ZA
dc.contributor.advisorNassimbeni, Luigi Ren_ZA
dc.contributor.authorDe Vries, Elise Janine Christlen_ZA
dc.date.accessioned2014-08-13T14:26:07Z
dc.date.available2014-08-13T14:26:07Z
dc.date.issued2003en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe aim of this thesis was to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to establish the detailed mode of drug inclusion in the solid state. Cyclodextrins and their derivatives have a low polarity central void formed by linked glucose residues of varying numbers. This annular cavity is able to encapsualte low molecular weight molecules and is therefore responsible for the great interest in CDs in host-guest chemistry. In addition, inclusion of drug molecules in cyclodextrins can significantly improve aspects of their performance, such as increased aqueous solubility and dissolution rates which lead to their increasing application in the pharmaceutical industry.en_ZA
dc.identifier.apacitationDe Vries, E. J. C. (2003). <i>Inclusion of alkylparabens in cyclodextrins</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6302en_ZA
dc.identifier.chicagocitationDe Vries, Elise Janine Christl. <i>"Inclusion of alkylparabens in cyclodextrins."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2003. http://hdl.handle.net/11427/6302en_ZA
dc.identifier.citationDe Vries, E. 2003. Inclusion of alkylparabens in cyclodextrins. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - De Vries, Elise Janine Christl AB - The aim of this thesis was to prepare crystalline inclusion complexes with cyclodextrins (CDs), as hosts, and drugs, as guests, characterise them using various methods and attempt to elucidate their structures by X-ray diffraction methods to establish the detailed mode of drug inclusion in the solid state. Cyclodextrins and their derivatives have a low polarity central void formed by linked glucose residues of varying numbers. This annular cavity is able to encapsualte low molecular weight molecules and is therefore responsible for the great interest in CDs in host-guest chemistry. In addition, inclusion of drug molecules in cyclodextrins can significantly improve aspects of their performance, such as increased aqueous solubility and dissolution rates which lead to their increasing application in the pharmaceutical industry. DA - 2003 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2003 T1 - Inclusion of alkylparabens in cyclodextrins TI - Inclusion of alkylparabens in cyclodextrins UR - http://hdl.handle.net/11427/6302 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6302
dc.identifier.vancouvercitationDe Vries EJC. Inclusion of alkylparabens in cyclodextrins. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2003 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6302en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleInclusion of alkylparabens in cyclodextrinsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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