Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study

Simple item page
dc.contributor.advisorNaude, Petrus
dc.contributor.advisorHowells Fleur
dc.contributor.authorWilliams, Kimberley Clare
dc.date.accessioned2023-09-12T09:33:55Z
dc.date.available2023-09-12T09:33:55Z
dc.date.issued2023
dc.date.updated2023-09-12T09:29:21Z
dc.description.abstractIntroduction: Schizophrenia (SCZ) and methamphetamine-induced psychotic disorder (MPD), are psychotic disorders characterized by positive symptoms (e.g., hallucinations and delusions), negative symptoms (e.g., social withdrawal, apathy), and impaired cognitive function. Despite the overlap in the clinical presentation of SCZ and MPD, no studies have compared electroencephalography (EEG) and inflammation across these two conditions. This study aimed to investigate key differences in brain electrical activity on EEG between SCZ and MPD by investigating; (1) relative frequency (alpha, theta, beta and delta) at rest; (2) cognitive performance and relative frequency activity during the continuous performance task (CPT) and cued target detection task (CTD); (3) differences in the P300 event-related potential waveform (ERP), a measure of attention, during the CPT and CTD; (4) cognitive performance and relative frequency and ERP (N170, P300) during the STROOP task, a measure of working memory and executive function; (5) the associations of (neuro) inflammatory markers with relative frequency and the P300 ERP waveform. Methods: 104 South African individuals, between the ages of 20 and 45 years, participated in this study: 69 outpatients (38 with SCZ (8 females/30 males), 31 with MPD (7 females/24 males)), and 35 healthy controls (CON: 15 females/20 males). All participants underwent a Structured Clinical Interview for Diagnostic Systematic Manual-IV (SCID-DSM-IV), with modifications to include changes made in DSM-5. EEG band frequency oscillations were recorded during baseline conditions: resting eyes open and resting eyes closed, and cognitive tasks (CPT, CTD and the Stroop task). Blood was drawn via venepuncture and serum was used for the analysis of cytokines (interleukin (IL) -1β IL-8, IL-10, IL-12p70, tumour necrosis factor-alpha and interferon-gamma (IFN-γ)) concentrations. Statistical analysis included assessment of normality using the Shapiro- Wilk test, with univariate one-way analysis of variance (ANOVA) of parametric data, and multiple independent Kruskal-Wallis ANOVA for non-parametric data (p)
dc.identifier.apacitationWilliams, K. C. (2023). <i>Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study</i>. (). ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health. Retrieved from http://hdl.handle.net/11427/38551en_ZA
dc.identifier.chicagocitationWilliams, Kimberley Clare. <i>"Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study."</i> ., ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2023. http://hdl.handle.net/11427/38551en_ZA
dc.identifier.citationWilliams, K.C. 2023. Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study. . ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health. http://hdl.handle.net/11427/38551en_ZA
dc.identifier.ris TY - Doctoral Thesis AU - Williams, Kimberley Clare AB - Introduction: Schizophrenia (SCZ) and methamphetamine-induced psychotic disorder (MPD), are psychotic disorders characterized by positive symptoms (e.g., hallucinations and delusions), negative symptoms (e.g., social withdrawal, apathy), and impaired cognitive function. Despite the overlap in the clinical presentation of SCZ and MPD, no studies have compared electroencephalography (EEG) and inflammation across these two conditions. This study aimed to investigate key differences in brain electrical activity on EEG between SCZ and MPD by investigating; (1) relative frequency (alpha, theta, beta and delta) at rest; (2) cognitive performance and relative frequency activity during the continuous performance task (CPT) and cued target detection task (CTD); (3) differences in the P300 event-related potential waveform (ERP), a measure of attention, during the CPT and CTD; (4) cognitive performance and relative frequency and ERP (N170, P300) during the STROOP task, a measure of working memory and executive function; (5) the associations of (neuro) inflammatory markers with relative frequency and the P300 ERP waveform. Methods: 104 South African individuals, between the ages of 20 and 45 years, participated in this study: 69 outpatients (38 with SCZ (8 females/30 males), 31 with MPD (7 females/24 males)), and 35 healthy controls (CON: 15 females/20 males). All participants underwent a Structured Clinical Interview for Diagnostic Systematic Manual-IV (SCID-DSM-IV), with modifications to include changes made in DSM-5. EEG band frequency oscillations were recorded during baseline conditions: resting eyes open and resting eyes closed, and cognitive tasks (CPT, CTD and the Stroop task). Blood was drawn via venepuncture and serum was used for the analysis of cytokines (interleukin (IL) -1β IL-8, IL-10, IL-12p70, tumour necrosis factor-alpha and interferon-gamma (IFN-γ)) concentrations. Statistical analysis included assessment of normality using the Shapiro- Wilk test, with univariate one-way analysis of variance (ANOVA) of parametric data, and multiple independent Kruskal-Wallis ANOVA for non-parametric data (p) DA - 2023 DB - OpenUCT DP - University of Cape Town KW - cognition in schizophrenia LK - https://open.uct.ac.za PY - 2023 T1 - Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study TI - Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study UR - http://hdl.handle.net/11427/38551 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/38551
dc.identifier.vancouvercitationWilliams KC. Investigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study. []. ,Faculty of Health Sciences ,Department of Psychiatry and Mental Health, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/38551en_ZA
dc.language.rfc3066eng
dc.publisher.departmentDepartment of Psychiatry and Mental Health
dc.publisher.facultyFaculty of Health Sciences
dc.subjectcognition in schizophrenia
dc.titleInvestigating cortical arousal and cognition in schizophrenia and methamphetamine-induced psychotic disorder: an electroencephalography and cytokine study
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationlevelPhD
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2023_williams kimberley clare.pdf
Size:
4.63 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
PhD / Doctoral