Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis

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dc.contributor.authorJoffe, Hymie Simonen_ZA
dc.date.accessioned2018-02-12T08:47:28Z
dc.date.available2018-02-12T08:47:28Z
dc.date.issued1979en_ZA
dc.description.abstractThis prospective study of acute myocarditis (AM) and endocardial fibroelastosis (EFE) was prompted by their common occurrence in infants and children in Cape Town, and by the persisting controversy regarding the possible relationship of these two conditions to each other, and to idiopathic, chronic, congestive cardiomyopathy (COCM). Patients with AM and EFE were analysed concurrently and over the long-term. The following hypotheses were investigated: A) that AM and EFE represent different phases of a common disease process, and B) that either AM or EFE evolves into COCM. From 1st June 1970 to 31st December 1976 (a study period of 6 years 7 months), 140 consecutive patients with AM or EFE were evaluated, and continually observed until 31st March 1979 (a total observation period of 8 years 10 months). Because there is no definitive, non-invasive, in-vivo diagnostic test for AM or EFE, an inclusive diagnosis of acute endomyocardial disease (EMD) was made in 123 patients who fulfilled all 4 rigid clinical criteria, i.e. a short history ( < 1 month), clinical evidence of myocardial involvement (heart failure, gallop rhythm or shock), radiological cardiomegaly (CTR > 0.55), and ST/T wave changes on electrocardiogram (ECG). Acute EMD was confirmed in all 20 patients who came to autopsy. A further 17 patients with insufficient clinical data had EMD at post-mortem.en_ZA
dc.identifier.apacitationJoffe, H. S. (1979). <i>Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/27518en_ZA
dc.identifier.chicagocitationJoffe, Hymie Simon. <i>"Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 1979. http://hdl.handle.net/11427/27518en_ZA
dc.identifier.citationJoffe, H. 1979. Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Joffe, Hymie Simon AB - This prospective study of acute myocarditis (AM) and endocardial fibroelastosis (EFE) was prompted by their common occurrence in infants and children in Cape Town, and by the persisting controversy regarding the possible relationship of these two conditions to each other, and to idiopathic, chronic, congestive cardiomyopathy (COCM). Patients with AM and EFE were analysed concurrently and over the long-term. The following hypotheses were investigated: A) that AM and EFE represent different phases of a common disease process, and B) that either AM or EFE evolves into COCM. From 1st June 1970 to 31st December 1976 (a study period of 6 years 7 months), 140 consecutive patients with AM or EFE were evaluated, and continually observed until 31st March 1979 (a total observation period of 8 years 10 months). Because there is no definitive, non-invasive, in-vivo diagnostic test for AM or EFE, an inclusive diagnosis of acute endomyocardial disease (EMD) was made in 123 patients who fulfilled all 4 rigid clinical criteria, i.e. a short history ( < 1 month), clinical evidence of myocardial involvement (heart failure, gallop rhythm or shock), radiological cardiomegaly (CTR > 0.55), and ST/T wave changes on electrocardiogram (ECG). Acute EMD was confirmed in all 20 patients who came to autopsy. A further 17 patients with insufficient clinical data had EMD at post-mortem. DA - 1979 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1979 T1 - Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis TI - Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis UR - http://hdl.handle.net/11427/27518 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27518
dc.identifier.vancouvercitationJoffe HS. Acute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 1979 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27518en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Paediatrics and Child Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMyocardial diseases in infancy and childhooden_ZA
dc.subject.otherEndomyocardial fibrosis in infancy and childhooden_ZA
dc.titleAcute endomyocardial disease in infants and children : the relationship between acute myocarditis and endocardial fibroelastosisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameMDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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