Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man

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dc.contributor.advisorNoakes, Timothy Den_ZA
dc.contributor.advisorDennis, Steveen_ZA
dc.contributor.authorHawley, John Alanen_ZA
dc.date.accessioned2018-01-30T13:37:58Z
dc.date.available2018-01-30T13:37:58Z
dc.date.issued1993en_ZA
dc.description.abstractSeveral factors may determine the rate. at which exogenous carbohydrate (CHO) is utilised by the human working muscles during prolonged (> 90 min moderate-intensity (63% of peak sustained power output [PPO]) exercise. These include i) the rate of gastric emptying of an ingested fluid, ii) the rate of digestion, absorption and subsequent transport of glucose into the systemic circulation, and iii) the rate of glucose uptake and oxidation by the working muscles. To test the hypothesis that the rate of gastric emptying is the primary factor limiting the rate of CHO delivery to the working muscles during exercise, uniformly labelled ¹⁴carbon (U-¹⁴C) tracer techniques were used in association with conventional gas exchange measurements and post-exercise gastric aspiration to compare the rates of gastric emptying, intestinal CHO delivery and ingested CHO oxidation from 15 g/100 ml solutions of glucose, maltose, a 22 chain-length glucose polymer, and an isocaloric 'soluble' starch preparation. Two groups of six highly-trained male cyclists or triathletes each ingested two of the test drinks which were given as a 400 ml loading bolus immediately before and then as eight 100 ml feedings at 10 min intervals during 90 min of continuous cycling at a work rate of 63% of PPO (~70% of maximal oxygen consumption [VO₂ₘₐₓ]).en_ZA
dc.identifier.apacitationHawley, J. A. (1993). <i>Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine. Retrieved from http://hdl.handle.net/11427/27121en_ZA
dc.identifier.chicagocitationHawley, John Alan. <i>"Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 1993. http://hdl.handle.net/11427/27121en_ZA
dc.identifier.citationHawley, J. 1993. Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Hawley, John Alan AB - Several factors may determine the rate. at which exogenous carbohydrate (CHO) is utilised by the human working muscles during prolonged (> 90 min moderate-intensity (63% of peak sustained power output [PPO]) exercise. These include i) the rate of gastric emptying of an ingested fluid, ii) the rate of digestion, absorption and subsequent transport of glucose into the systemic circulation, and iii) the rate of glucose uptake and oxidation by the working muscles. To test the hypothesis that the rate of gastric emptying is the primary factor limiting the rate of CHO delivery to the working muscles during exercise, uniformly labelled ¹⁴carbon (U-¹⁴C) tracer techniques were used in association with conventional gas exchange measurements and post-exercise gastric aspiration to compare the rates of gastric emptying, intestinal CHO delivery and ingested CHO oxidation from 15 g/100 ml solutions of glucose, maltose, a 22 chain-length glucose polymer, and an isocaloric 'soluble' starch preparation. Two groups of six highly-trained male cyclists or triathletes each ingested two of the test drinks which were given as a 400 ml loading bolus immediately before and then as eight 100 ml feedings at 10 min intervals during 90 min of continuous cycling at a work rate of 63% of PPO (~70% of maximal oxygen consumption [VO₂ₘₐₓ]). DA - 1993 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1993 T1 - Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man TI - Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man UR - http://hdl.handle.net/11427/27121 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/27121
dc.identifier.vancouvercitationHawley JA. Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,MRC/UCT RU for Exercise and Sport Medicine, 1993 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/27121en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentMRC/UCT RU for Exercise and Sport Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherExercise - physiologyen_ZA
dc.subject.otherGlucose - Metabolismen_ZA
dc.subject.otherMedical Physiologyen_ZA
dc.titleLimits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in manen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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