The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.

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dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.advisorSchwegmann, Anitaen_ZA
dc.contributor.authorSmith, Liezel Cen_ZA
dc.date.accessioned2014-07-28T14:54:11Z
dc.date.available2014-07-28T14:54:11Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractLeishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis. The study aims to determine how signaling via the IL-4Rα on CD4+T cells causes susceptibility to L. major. We compared gene expression patterns early during infection in CD4+ T cells in the absence or presence of IL-4Rα signaling. Non-healer BALB/c mice with a deletion of the IL-4Rα on all cells (IL-4Rα-/-) or CD4+ T cells only (iLCKcreIL-4Rαlox/-) and their controls (wild-type (WT) C57BL/6, WT BALB/c and littermate IL-4Rαlox/-) were subcutaneously infected with L. major. As expected, the C57BL/6 “healer” mice produced a predominant TH1 response, whereas the iLCKcreIL-4Rα-/lox mice and susceptible BALB/c mice produced a TH2 response.en_ZA
dc.identifier.apacitationSmith, L. C. (2013). <i>The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/3118en_ZA
dc.identifier.chicagocitationSmith, Liezel C. <i>"The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2013. http://hdl.handle.net/11427/3118en_ZA
dc.identifier.citationSmith, L. 2013. The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smith, Liezel C AB - Leishmania major is a protozoan parasite and infection in the human host causes severe cutaneous Leishmaniasis. The study aims to determine how signaling via the IL-4Rα on CD4+T cells causes susceptibility to L. major. We compared gene expression patterns early during infection in CD4+ T cells in the absence or presence of IL-4Rα signaling. Non-healer BALB/c mice with a deletion of the IL-4Rα on all cells (IL-4Rα-/-) or CD4+ T cells only (iLCKcreIL-4Rαlox/-) and their controls (wild-type (WT) C57BL/6, WT BALB/c and littermate IL-4Rαlox/-) were subcutaneously infected with L. major. As expected, the C57BL/6 “healer” mice produced a predominant TH1 response, whereas the iLCKcreIL-4Rα-/lox mice and susceptible BALB/c mice produced a TH2 response. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics TI - The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics UR - http://hdl.handle.net/11427/3118 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3118
dc.identifier.vancouvercitationSmith LC. The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3118en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleThe role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.en_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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