Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV

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dc.contributor.advisorDenti, Paolo
dc.contributor.advisorHesseling, Anneke
dc.contributor.advisorGarcia-Prats, Anthony
dc.contributor.authorVan der Laan, Louvina Elizabeth
dc.date.accessioned2025-03-31T07:58:36Z
dc.date.available2025-03-31T07:58:36Z
dc.date.issued2024
dc.date.updated2025-03-31T07:56:43Z
dc.description.abstractThe global burden of rifampicin- and/or multidrug-resistant (RR/MDR) -TB, i.e. Mycobacterium tuberculosis resistant to rifampicin and/or isoniazid is increasing, especially in settings with high HIV prevalence. Optimising the prevention and treatment of RR/MDR-TB in children in such settings is critically important. Population pharmacokinetic modelling, the state-of-the art technique to interpret pharmacological data, can play a pivotal role for therapeutic optimization in children, since it enables characterisation and inclusion of the effects of important developmental factors, thus allowing for determination and evaluation of effective yet safe RR/MDR treatment in children.
dc.identifier.apacitationVan der Laan, L. E. (2024). <i>Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV</i>. (). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/41299en_ZA
dc.identifier.chicagocitationVan der Laan, Louvina Elizabeth. <i>"Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV."</i> ., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2024. http://hdl.handle.net/11427/41299en_ZA
dc.identifier.citationVan der Laan, L.E. 2024. Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV. . University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. http://hdl.handle.net/11427/41299en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van der Laan, Louvina Elizabeth AB - The global burden of rifampicin- and/or multidrug-resistant (RR/MDR) -TB, i.e. Mycobacterium tuberculosis resistant to rifampicin and/or isoniazid is increasing, especially in settings with high HIV prevalence. Optimising the prevention and treatment of RR/MDR-TB in children in such settings is critically important. Population pharmacokinetic modelling, the state-of-the art technique to interpret pharmacological data, can play a pivotal role for therapeutic optimization in children, since it enables characterisation and inclusion of the effects of important developmental factors, thus allowing for determination and evaluation of effective yet safe RR/MDR treatment in children. DA - 2024 DB - OpenUCT DP - University of Cape Town KW - Rifampicin-resistant TB KW - HIV LK - https://open.uct.ac.za PB - University of Cape Town PY - 2024 T1 - Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV TI - Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV UR - http://hdl.handle.net/11427/41299 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/41299
dc.identifier.vancouvercitationVan der Laan LE. Population pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV. []. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2024 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/41299en_ZA
dc.language.isoen
dc.language.rfc3066ENG
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subjectRifampicin-resistant TB
dc.subjectHIV
dc.titlePopulation pharmacokinetic modelling to optimise treatment for children with Rifampicin-resistant TB and HIV
dc.typeThesis / Dissertation
dc.type.qualificationlevelDoctoral
dc.type.qualificationlevelPhD
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