Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors

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dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.advisorSchwellnus, Martinen_ZA
dc.contributor.authorMokone, Gaonyadiwe Georgeen_ZA
dc.date.accessioned2014-07-28T18:17:33Z
dc.date.available2014-07-28T18:17:33Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractThis main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6).en_ZA
dc.identifier.apacitationMokone, G. G. (2006). <i>Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3270en_ZA
dc.identifier.chicagocitationMokone, Gaonyadiwe George. <i>"Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006. http://hdl.handle.net/11427/3270en_ZA
dc.identifier.citationMokone, G. 2006. Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mokone, Gaonyadiwe George AB - This main purpose of this thesis was therefore to investigate whether any specific genes on the tip of the long arm of chromosome 9 were associated with Achilles tendon injuries, using a case-control study design. The specific objectives were: (i) to identify all genes located in the 9q32-q34.3 locus in close proximity to the ABO gene, that could be involved in tendon injuries (Chapter 2) and (ii) to investigate the possible association of the identified candidate genes (COL5A1 and TNC with both Achilles tendon rupture and chronic Achilles tendinopathy (Chapter 3 and 4) and (iii) finally to investigate the possible interaction of these two genes with tendon function, namely the muscle-tendon unit flexibility (chapter 5) and structure, namely the morphological changes of the Achilles tendon (Chapter 6). DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors TI - Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors UR - http://hdl.handle.net/11427/3270 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3270
dc.identifier.vancouvercitationMokone GG. Risk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factors. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3270en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleRisk factors for Achilles tendon injuries : an emphasis on the identification of specific genetic factorsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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