Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorOctober, Natashaen_ZA
dc.date.accessioned2014-08-13T14:28:56Z
dc.date.available2014-08-13T14:28:56Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractFor many years malaria has been a major cause of human suffering. Despite significant advances in understanding the disease and the parasite, malaria still remains one of the leading causes of morbidity and mortality, particularly in the tropics. Approximately 500 million people are afflicted and almost 3 million people die from the disease annually. Of the four causative species, Plasmodium falciparum is the most lethal. Recent trends indicate rapid emergence of drug-resistent and more virulent strains of the parasite to further intensify the problem. The choice of therapies currently available for the treatment of malaria is highly limited, and several of these may eventually be lost or compromised due to drug resistance. New antimalarial drugs with proven clinical efficacy against current drug-resistance cases of malaria including Plasmodium falciparum infections is critical to combact the disease and cope with the problem of further development or resistance.en_ZA
dc.identifier.apacitationOctober, N. (2006). <i>Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6353en_ZA
dc.identifier.chicagocitationOctober, Natasha. <i>"Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2006. http://hdl.handle.net/11427/6353en_ZA
dc.identifier.citationOctober, N. 2006. Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - October, Natasha AB - For many years malaria has been a major cause of human suffering. Despite significant advances in understanding the disease and the parasite, malaria still remains one of the leading causes of morbidity and mortality, particularly in the tropics. Approximately 500 million people are afflicted and almost 3 million people die from the disease annually. Of the four causative species, Plasmodium falciparum is the most lethal. Recent trends indicate rapid emergence of drug-resistent and more virulent strains of the parasite to further intensify the problem. The choice of therapies currently available for the treatment of malaria is highly limited, and several of these may eventually be lost or compromised due to drug resistance. New antimalarial drugs with proven clinical efficacy against current drug-resistance cases of malaria including Plasmodium falciparum infections is critical to combact the disease and cope with the problem of further development or resistance. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum TI - Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum UR - http://hdl.handle.net/11427/6353 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6353
dc.identifier.vancouvercitationOctober N. Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6353en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleDesign, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparumen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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