Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome

Doctoral Thesis

2011

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http://hdl.handle.net/11427/11589
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thesis_hsf_2011_tadokera_r.pdf (10.65 MB)
Authors
Tadokera, Rabecca
Supervisors
Wilkinson, Robert J
Wilkinson, Katalin
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University of Cape Town

Department
Institute of Infectious Disease and Molecular Medicine
Faculty
Faculty of Health Sciences
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Abstract
While the integration of anti-TB and cART therapies is associated with substantial clinical improvement in the majority of patients, HIV-Tuberculosis associated Immune Reconstitution Inflammatory Syndrome (TB-IRIS) has been shown to occur in a significant subset of these patients. TB-IRIS is an inflammatory complication of the combined treatments for HIV-1 and tuberculosis, which is being reported increasingly, particularly in areas endemic to both diseases. This work aimed to characterise the immunopathogenesis of paradoxical HIV-Tuberculosis associated immune reconstitution inflammatory syndrome.
Description
Keywords
Infectious Diseases

Reference:

Tadokera, R. 2011. Immunological characterization of the HIV-tuberculosis associated immune reconstitution inflammatory syndrome. University of Cape Town.

Collections
PhD / Doctoral