Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

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dc.contributor.authorWhite, Nicholas J
dc.contributor.authorAshley, Elizabeth A
dc.contributor.authorRecht, Judith
dc.contributor.authorDelves, Michael J
dc.contributor.authorRuecker, Andrea
dc.contributor.authorSmithuis, Frank M
dc.contributor.authorEziefula, Alice C
dc.contributor.authorBousema, Teun
dc.contributor.authorDrakeley, Chris
dc.contributor.authorChotivanich, Kesinee
dc.contributor.authorImwong, Mallika
dc.contributor.authorPukrittayakamee, Sasithon
dc.contributor.authorPrachumsri, Jetsumon
dc.contributor.authorChu, Cindy
dc.contributor.authorAndolina, Chiara
dc.contributor.authorBancone, Germana
dc.contributor.authorHien, Tran T
dc.contributor.authorMayxay, Mayfong
dc.contributor.authorTaylor, Walter R
dc.contributor.authorvon Seidlein, Lorenz
dc.contributor.authorPrice, Ric N
dc.contributor.authorBarnes, Karen I
dc.contributor.authorDjimdé, Abdoulaye
dc.contributor.authorter Kuile, Feiko
dc.contributor.authorGosling, Roly
dc.contributor.authorChen, Ingrid
dc.contributor.authorDhorda, Mehul J
dc.contributor.authorStepniewska, Kasia
dc.contributor.authorGuérin, Philippe
dc.contributor.authorWoodrow, Charles J
dc.contributor.authorDondorp, Arjen M
dc.contributor.authorDay, Nicholas P
dc.contributor.authorNosten, Francois H
dc.date.accessioned2015-07-30T03:57:50Z
dc.date.available2015-07-30T03:57:50Z
dc.date.issued2014-12-09
dc.date.updated2015-05-05T18:01:21Z
dc.description.abstractAbstract Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
dc.identifier.apacitationWhite, N. J., Ashley, E. A., Recht, J., Delves, M. J., Ruecker, A., Smithuis, F. M., ... Nosten, F. H. (2014). Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. <i>Malaria Journal</i>, http://hdl.handle.net/11427/13599en_ZA
dc.identifier.chicagocitationWhite, Nicholas J, Elizabeth A Ashley, Judith Recht, Michael J Delves, Andrea Ruecker, Frank M Smithuis, Alice C Eziefula, et al "Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria." <i>Malaria Journal</i> (2014) http://hdl.handle.net/11427/13599en_ZA
dc.identifier.citationWhite, N. J., Ashley, E. A., Recht, J., Delves, M. J., Ruecker, A., Smithuis, F. M., ... & Nosten, F. H. (2014). Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria journal, 13(1), 483.
dc.identifier.ris TY - Journal Article AU - White, Nicholas J AU - Ashley, Elizabeth A AU - Recht, Judith AU - Delves, Michael J AU - Ruecker, Andrea AU - Smithuis, Frank M AU - Eziefula, Alice C AU - Bousema, Teun AU - Drakeley, Chris AU - Chotivanich, Kesinee AU - Imwong, Mallika AU - Pukrittayakamee, Sasithon AU - Prachumsri, Jetsumon AU - Chu, Cindy AU - Andolina, Chiara AU - Bancone, Germana AU - Hien, Tran T AU - Mayxay, Mayfong AU - Taylor, Walter R AU - von Seidlein, Lorenz AU - Price, Ric N AU - Barnes, Karen I AU - Djimdé, Abdoulaye AU - ter Kuile, Feiko AU - Gosling, Roly AU - Chen, Ingrid AU - Dhorda, Mehul J AU - Stepniewska, Kasia AU - Guérin, Philippe AU - Woodrow, Charles J AU - Dondorp, Arjen M AU - Day, Nicholas P AU - Nosten, Francois H AB - Abstract Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies. DA - 2014-12-09 DB - OpenUCT DO - 10.1186/1475-2875-13-483 DP - University of Cape Town J1 - Malaria Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria TI - Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria UR - http://hdl.handle.net/11427/13599 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13599
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2875-13-483
dc.identifier.vancouvercitationWhite NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, et al. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria Journal. 2014; http://hdl.handle.net/11427/13599.en_ZA
dc.language.rfc3066en
dc.publisher.departmentDivision of Clinical Pharmacologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License*
dc.rights.holderWhite et al.; licensee BioMed Central.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0*
dc.sourceMalaria Journalen_ZA
dc.source.urihttp://www.malariajournal.com
dc.titleAssessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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