Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria

Journal Article

2014-12-09

Permanent link to this Item
http://hdl.handle.net/11427/13599
 http://dx.doi.org/10.1186/1475-2875-13-483
Files
White_Assessment_of_therapeutic_responses_2014.pdf (2.24 MB)
Authors
White, Nicholas J
Ashley, Elizabeth A
Imwong, Mallika
Pukrittayakamee, Sasithon
Prachumsri, Jetsumon
Chu, Cindy
Andolina, Chiara
Bancone, Germana
Hien, Tran T
Mayxay, Mayfong
Taylor, Walter R
von Seidlein, Lorenz
Recht, Judith
Price, Ric N
Barnes, Karen I
Djimdé, Abdoulaye
ter Kuile, Feiko
Gosling, Roly
Chen, Ingrid
Dhorda, Mehul J
Stepniewska, Kasia
Guérin, Philippe
Woodrow, Charles J
Delves, Michael J
Dondorp, Arjen M
Day, Nicholas P
Nosten, Francois H
Ruecker, Andrea
Smithuis, Frank M
Eziefula, Alice C
Bousema, Teun
Drakeley, Chris
Chotivanich, Kesinee
Journal Title

Malaria Journal

Link to Journal
http://www.malariajournal.com
Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Division of Clinical Pharmacology
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/4.0

Series
Abstract
Abstract Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.
Description

Reference:

White, N. J., Ashley, E. A., Recht, J., Delves, M. J., Ruecker, A., Smithuis, F. M., ... & Nosten, F. H. (2014). Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malaria journal, 13(1), 483.

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