A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae

Master Thesis

2002

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http://hdl.handle.net/11427/4250
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thesis_sci_2002_coert_c.pdf (5.09 MB)
Authors
Coert, Claudette
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University of Cape Town

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Department of Molecular and Cell Biology
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Faculty of Science
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Abstract
It is well established that histone H1 is involved in facilitating the higher-order structures of chromatin. It has not become possible to test the biochemical function of H1 in Saccharomyces cerevisiae, since the identification of a H1 homologue (Landsman, 1996) with properties of a bona fide linker histone (Patterton et al., 1998; Ali, 2000). Such studies were difficult since no phenotype for a HHO1 deleted strain has been published. In this study I have investigated the response of an HHO1 disrupted strain to numerous conditions including UV radiation, osmotic and oxidative stress, y-irradiation and longevity.
Description

Bibliography: leaves 90-111.

Keywords
Cell Biology

Reference:

Coert, C. 2002. A role for Hho1p, a histone H1 homologue, in Saccharomyces cerevisiae. University of Cape Town.

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