Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts

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dc.contributor.advisorParker, Iqbalen_ZA
dc.contributor.authorDzobo, Kevinen_ZA
dc.date.accessioned2014-07-28T14:54:51Z
dc.date.available2014-07-28T14:54:51Z
dc.date.issued2009en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (leaves 122-157).
dc.description.abstractStromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the most abundant extracellular matrix protein in the human body and is found in tissues requiring high tensile strength. In this study we investigated the effect of a pre-formed fibroblast-derived extracellular matrix on the expression of type I collagen and associated matrix metalloproteinases in fibroblasts.en_ZA
dc.identifier.apacitationDzobo, K. (2009). <i>Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/3125en_ZA
dc.identifier.chicagocitationDzobo, Kevin. <i>"Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2009. http://hdl.handle.net/11427/3125en_ZA
dc.identifier.citationDzobo, K. 2009. Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dzobo, Kevin AB - Stromal cells and the extracellular matrix (ECM) components provide the microenvironment that is pivotal for cell growth, motility, attachment and differentiation. Fibroblasts are some of the cells responsible for the synthesis of most of the extracellular matrix proteins. Type I collagen is the most abundant extracellular matrix protein in the human body and is found in tissues requiring high tensile strength. In this study we investigated the effect of a pre-formed fibroblast-derived extracellular matrix on the expression of type I collagen and associated matrix metalloproteinases in fibroblasts. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts TI - Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts UR - http://hdl.handle.net/11427/3125 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3125
dc.identifier.vancouvercitationDzobo K. Matrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblasts. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3125en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleMatrix-mediated regulation of type 1 collagen synthesis and degradation in cultured fibroblastsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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