Genetic risk factors for anterior cruciate ligament ruptures

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dc.contributor.advisorCollins, Malcolmen_ZA
dc.contributor.advisorSchwellnus, Martinen_ZA
dc.contributor.authorPosthumus, Michaelen_ZA
dc.date.accessioned2014-07-28T18:14:20Z
dc.date.available2014-07-28T18:14:20Z
dc.date.issued2009en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (p. 197-215).
dc.description.abstractThe primary aim of this thesis was to identify candidate genes that may be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide polymorphisms, SNPs) within these candidate genes which may predispose individuals to ACL ruptures. Candidate genes (COL1A1, COL5A1 and COL12A1) were selected based on the biological function of their encoded proteins (type I, type V and type XII collagen respectively) within the basic structural and functional unit of ligaments, namely the collagen microfibril.en_ZA
dc.identifier.apacitationPosthumus, M. (2009). <i>Genetic risk factors for anterior cruciate ligament ruptures</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/3195en_ZA
dc.identifier.chicagocitationPosthumus, Michael. <i>"Genetic risk factors for anterior cruciate ligament ruptures."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2009. http://hdl.handle.net/11427/3195en_ZA
dc.identifier.citationPosthumus, M. 2009. Genetic risk factors for anterior cruciate ligament ruptures. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Posthumus, Michael AB - The primary aim of this thesis was to identify candidate genes that may be associated with ACL ruptures, and then use a genetic association approach following a case-control study design to identify specific sequence variants (single nucleotide polymorphisms, SNPs) within these candidate genes which may predispose individuals to ACL ruptures. Candidate genes (COL1A1, COL5A1 and COL12A1) were selected based on the biological function of their encoded proteins (type I, type V and type XII collagen respectively) within the basic structural and functional unit of ligaments, namely the collagen microfibril. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - Genetic risk factors for anterior cruciate ligament ruptures TI - Genetic risk factors for anterior cruciate ligament ruptures UR - http://hdl.handle.net/11427/3195 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3195
dc.identifier.vancouvercitationPosthumus M. Genetic risk factors for anterior cruciate ligament ruptures. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3195en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleGenetic risk factors for anterior cruciate ligament rupturesen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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