β-Glucan exacerbates allergic airway responses to house dust mite allergen

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dc.contributor.authorHadebe, Sabelo
dc.contributor.authorKirstein, Frank
dc.contributor.authorFierens, Kaat
dc.contributor.authorRedelinghuys, Pierre
dc.contributor.authorMurray, Graeme I
dc.contributor.authorWilliams, David L
dc.contributor.authorLambrecht, Bart N
dc.contributor.authorBrombacher, Frank
dc.contributor.authorBrown, Gordon D
dc.date.accessioned2016-05-23T13:01:53Z
dc.date.available2016-05-23T13:01:53Z
dc.date.issued2016
dc.date.updated2016-05-19T09:23:03Z
dc.description.abstractβ-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.en_ZA
dc.identifier.apacitationHadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., ... Brown, G. D. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. <i>Respiratory Research</i>, http://hdl.handle.net/11427/19794en_ZA
dc.identifier.chicagocitationHadebe, Sabelo, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I Murray, David L Williams, Bart N Lambrecht, Frank Brombacher, and Gordon D Brown "β-Glucan exacerbates allergic airway responses to house dust mite allergen." <i>Respiratory Research</i> (2016) http://hdl.handle.net/11427/19794en_ZA
dc.identifier.citationHadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., ... & Brown, G. D. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17(1), 1.en_ZA
dc.identifier.issn1465-9921en_ZA
dc.identifier.ris TY - Journal Article AU - Hadebe, Sabelo AU - Kirstein, Frank AU - Fierens, Kaat AU - Redelinghuys, Pierre AU - Murray, Graeme I AU - Williams, David L AU - Lambrecht, Bart N AU - Brombacher, Frank AU - Brown, Gordon D AB - β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation. DA - 2016 DB - OpenUCT DO - 10.1186/s12931-016-0352-5 DP - University of Cape Town J1 - Respiratory Research LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 SM - 1465-9921 T1 - β-Glucan exacerbates allergic airway responses to house dust mite allergen TI - β-Glucan exacerbates allergic airway responses to house dust mite allergen UR - http://hdl.handle.net/11427/19794 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12931-016-0352-5
dc.identifier.urihttp://hdl.handle.net/11427/19794
dc.identifier.vancouvercitationHadebe S, Kirstein F, Fierens K, Redelinghuys P, Murray GI, Williams DL, et al. β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research. 2016; http://hdl.handle.net/11427/19794.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderHadebe et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceRespiratory Researchen_ZA
dc.source.urihttp://respiratory-research.biomedcentral.com/
dc.titleβ-Glucan exacerbates allergic airway responses to house dust mite allergenen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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