β-Glucan exacerbates allergic airway responses to house dust mite allergen

Journal Article

2016

Permanent link to this Item
http://dx.doi.org/10.1186/s12931-016-0352-5
 http://hdl.handle.net/11427/19794
Files
12931_2016_Article_352.pdf (1.19 MB)
Authors
Hadebe, Sabelo
Kirstein, Frank
Fierens, Kaat
Redelinghuys, Pierre
Murray, Graeme I
Williams, David L
Lambrecht, Bart N
Brombacher, Frank
Brown, Gordon D
Journal Title

Respiratory Research

Link to Journal
http://respiratory-research.biomedcentral.com/
Journal ISSN
Volume Title
Publisher

BioMed Central

Publisher

University of Cape Town

Department
Division of Immunology
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/4.0/

Series
Abstract
β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified β-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Derβ T cells). We therefore provide definitive evidence that β-glucan can influence allergic pulmonary inflammation.
Description

Reference:

Hadebe, S., Kirstein, F., Fierens, K., Redelinghuys, P., Murray, G. I., Williams, D. L., ... & Brown, G. D. (2016). β-Glucan exacerbates allergic airway responses to house dust mite allergen. Respiratory Research, 17(1), 1.

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