Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.advisorMaharaj, Vineshen_ZA
dc.contributor.authorPillay, Pamishaen_ZA
dc.date.accessioned2014-08-13T14:29:27Z
dc.date.available2014-08-13T14:29:27Z
dc.date.issued2011en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractTrema orientalis, a widely distributed evergreen tree with various medicinal properties including the treatment of malaria, was investigated as a potential source of new antimalarial lead compounds. Organic extracts of the young growing twigs of T. orientalis were reproducibly shown to be active against the chloroquine-sensitive (D10) and chloroquine resistant (K1) strains of Plasmodium falciparum. The 8-O-4' oxyneolignans, dadahols A and B, were identified as the major active compounds using two bioassay-guided fractionation approaches. The new accelerated “HPLC biogram” methodology allowed for early recognition of the active compounds in the complex plant extract, requiring considerably less time and material compared to the classical reiterative approach.en_ZA
dc.identifier.apacitationPillay, P. (2011). <i>Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6357en_ZA
dc.identifier.chicagocitationPillay, Pamisha. <i>"Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011. http://hdl.handle.net/11427/6357en_ZA
dc.identifier.citationPillay, P. 2011. Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Pillay, Pamisha AB - Trema orientalis, a widely distributed evergreen tree with various medicinal properties including the treatment of malaria, was investigated as a potential source of new antimalarial lead compounds. Organic extracts of the young growing twigs of T. orientalis were reproducibly shown to be active against the chloroquine-sensitive (D10) and chloroquine resistant (K1) strains of Plasmodium falciparum. The 8-O-4' oxyneolignans, dadahols A and B, were identified as the major active compounds using two bioassay-guided fractionation approaches. The new accelerated “HPLC biogram” methodology allowed for early recognition of the active compounds in the complex plant extract, requiring considerably less time and material compared to the classical reiterative approach. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation TI - Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation UR - http://hdl.handle.net/11427/6357 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6357
dc.identifier.vancouvercitationPillay P. Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6357en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleAntiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.en_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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