Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis

Simple item page
dc.contributor.advisorSmith, Gregory Sen_ZA
dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorAdams, Muneebahen_ZA
dc.date.accessioned2016-07-18T12:54:41Z
dc.date.available2016-07-18T12:54:41Z
dc.date.issued2016en_ZA
dc.description.abstractMany successful initiatives have been employed to stem the spread of the diseases such as malaria and trichomonas's. However, in cases where infection has occurred, pharmaceutical treatments are required. A problem seen across the board is the development of resistance to known treatments. An even bigger problem has been the development of resistance to promising compounds during the clinical trial phase. This has led to the need for effective treatments which are able to overcome the resistance problem. This study investigated the synthesis, characterisation and pharmacological evaluation of new bioorganometallic organosilane-containing compounds based on thiosemicarbazone (TSC),quinoline and benzothiazole scaffolds. Selected thiosemicarbazone-containing ruthenium(II), rhodium(III) and palladium(II) metal complexes were also studied. The compounds were screened for antiplasmodial and antitrichomonal activity, along with their activity against A2780 human ovarian carcinoma and WHCO1 oesophageal cancer cell-lines.en_ZA
dc.identifier.apacitationAdams, M. (2016). <i>Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/20435en_ZA
dc.identifier.chicagocitationAdams, Muneebah. <i>"Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2016. http://hdl.handle.net/11427/20435en_ZA
dc.identifier.citationAdams, M. 2016. Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Adams, Muneebah AB - Many successful initiatives have been employed to stem the spread of the diseases such as malaria and trichomonas's. However, in cases where infection has occurred, pharmaceutical treatments are required. A problem seen across the board is the development of resistance to known treatments. An even bigger problem has been the development of resistance to promising compounds during the clinical trial phase. This has led to the need for effective treatments which are able to overcome the resistance problem. This study investigated the synthesis, characterisation and pharmacological evaluation of new bioorganometallic organosilane-containing compounds based on thiosemicarbazone (TSC),quinoline and benzothiazole scaffolds. Selected thiosemicarbazone-containing ruthenium(II), rhodium(III) and palladium(II) metal complexes were also studied. The compounds were screened for antiplasmodial and antitrichomonal activity, along with their activity against A2780 human ovarian carcinoma and WHCO1 oesophageal cancer cell-lines. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis TI - Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis UR - http://hdl.handle.net/11427/20435 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20435
dc.identifier.vancouvercitationAdams M. Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20435en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleDevelopment of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalisen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2016_adams_muneebah.pdf
Size:
3.22 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
PhD / Doctoral