Novel chemotherapeutic agents for oesophageal cancer

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dc.contributor.advisorHendricks, Denveren_ZA
dc.contributor.authorKhuzwayo, Londiwe Mandisaen_ZA
dc.date.accessioned2015-01-11T04:57:39Z
dc.date.available2015-01-11T04:57:39Z
dc.date.issued2012en_ZA
dc.descriptionIncludes abstract.en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractChemotherapeutic agents such as cisplatin, doxorubicin and 5-fluorouracil are currently used in the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been associated with their use in cancer therapy. Thus there is a need to develop novel chemotherapeutic agents with improved activity and less severe side effects. In this project, twelve compounds, consisting of 5 platinum dichloride complexes, four iminophosphine ligands and three gold (I) chloride complexes that were synthesised by a PhD student in our laboratory were tested for anticancer activity and the mode of action of these compounds was also explored.en_ZA
dc.identifier.apacitationKhuzwayo, L. M. (2012). <i>Novel chemotherapeutic agents for oesophageal cancer</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/12051en_ZA
dc.identifier.chicagocitationKhuzwayo, Londiwe Mandisa. <i>"Novel chemotherapeutic agents for oesophageal cancer."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2012. http://hdl.handle.net/11427/12051en_ZA
dc.identifier.citationKhuzwayo, L. 2012. Novel chemotherapeutic agents for oesophageal cancer. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Khuzwayo, Londiwe Mandisa AB - Chemotherapeutic agents such as cisplatin, doxorubicin and 5-fluorouracil are currently used in the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been associated with their use in cancer therapy. Thus there is a need to develop novel chemotherapeutic agents with improved activity and less severe side effects. In this project, twelve compounds, consisting of 5 platinum dichloride complexes, four iminophosphine ligands and three gold (I) chloride complexes that were synthesised by a PhD student in our laboratory were tested for anticancer activity and the mode of action of these compounds was also explored. DA - 2012 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2012 T1 - Novel chemotherapeutic agents for oesophageal cancer TI - Novel chemotherapeutic agents for oesophageal cancer UR - http://hdl.handle.net/11427/12051 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12051
dc.identifier.vancouvercitationKhuzwayo LM. Novel chemotherapeutic agents for oesophageal cancer. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2012 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12051en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Medical Biochemistryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Biochemistryen_ZA
dc.titleNovel chemotherapeutic agents for oesophageal canceren_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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