Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

Journal Article

2006

Permanent link to this Item
http://hdl.handle.net/11427/15337
 http://dx.doi.org/10.1371/journal.pmed.0030444
Files
Simpson_Population_Pharmacokinetics_2006.pdf (179.05 KB)
Authors
Simpson, Julie A
Agbenyega, Tsiri
Barnes, Karen I
Perri, Gianni Di
Folb, Peter
Gomes, Melba
Krishna, Sanjeev
Krudsood, Srivicha
Looareesuwan, Sornchai
Mansor, Sharif
Journal Title

PLOS Medicince

Link to Journal
http://journals.plos.org/plosmedicine
Journal ISSN
Volume Title
Publisher

Public Library of Science

Publisher

University of Cape Town

Department
Division of Clinical Pharmacology
Faculty
Faculty of Health Sciences
License

http://creativecommons.org/licenses/by/4.0

Series
Abstract
A study of the population pharmacokinetics of intra-rectal artesunate in patients with moderately severe falciparum malaria found the pharmacokinetic properties of dihydroartemisinin were affected only by gender and body weight.
Description
Keywords
Pharmacokinetics
Malaria
Malarial parasites
Drug therapy
Antimalarials
Drug absorption
Body weight
Pharmacokinetic analysis

Reference:

Simpson, J. A., Agbenyega, T., Barnes, K. I., Di Perri, G., Folb, P., Gomes, M., ... & White, N. J. (2006). Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients. PLoS Med, 3(11), e444. doi:10.1371/journal.pmed.0030444

Collections
Journal Articles