Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya

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dc.contributor.advisorRyffel, Bernharden_ZA
dc.contributor.authorOthoro, Carolineen_ZA
dc.date.accessioned2014-10-18T05:58:29Z
dc.date.available2014-10-18T05:58:29Z
dc.date.issued2003en_ZA
dc.descriptionBibliography: leaves 132-155.en_ZA
dc.description.abstractWomen during pregnancy in holoendemic regions of malaria are at an increased risk for peripheral malaria infections with potential for developing placental malaria. The immunological basis of protection and pathogenesis are incompletely understood. This thesis investigates both processes. Research on maternal placental immune responses necessitates the collection of reliable placental intervillous blood; an appropriate method for placental blood collection was therefore first determined. Five documented methods of collection (perfusion, incision, biopsy, tissue grinding and prick) were compared for foetal blood contamination and mononuclear cell profiles using flow cytometry. Placental blood collection by prick was established as the most appropriate method and was subsequently used for further immunological investigations.en_ZA
dc.identifier.apacitationOthoro, C. (2003). <i>Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/8597en_ZA
dc.identifier.chicagocitationOthoro, Caroline. <i>"Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2003. http://hdl.handle.net/11427/8597en_ZA
dc.identifier.citationOthoro, C. 2003. Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Othoro, Caroline AB - Women during pregnancy in holoendemic regions of malaria are at an increased risk for peripheral malaria infections with potential for developing placental malaria. The immunological basis of protection and pathogenesis are incompletely understood. This thesis investigates both processes. Research on maternal placental immune responses necessitates the collection of reliable placental intervillous blood; an appropriate method for placental blood collection was therefore first determined. Five documented methods of collection (perfusion, incision, biopsy, tissue grinding and prick) were compared for foetal blood contamination and mononuclear cell profiles using flow cytometry. Placental blood collection by prick was established as the most appropriate method and was subsequently used for further immunological investigations. DA - 2003 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2003 T1 - Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya TI - Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya UR - http://hdl.handle.net/11427/8597 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/8597
dc.identifier.vancouvercitationOthoro C. Investigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenya. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2003 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/8597en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleInvestigations of cellular immune mechanisms to malaria during pregnancy in a malaria holoendemic region of Western Kenyaen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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