The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.

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dc.contributor.advisorPrince, Sharonen_ZA
dc.contributor.authorWansleben, Sabina Mariaen_ZA
dc.date.accessioned2014-07-30T17:50:15Z
dc.date.available2014-07-30T17:50:15Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractT-box genes constitute an ancient family of developmentally important transcription factors that have gained prominence in cancer biology. For example, endogenous TBX2 is overexpressed in a growing list of cancers and when ectopically overexpressed it can bypass senescence and the tetraploidy checkpoints that protect against cancer. When the current study was initiated it was unclear as to whether the endogenous overexpression of TBX2 was a cause or consequence of the oncogenic process and whether it may be a suitable anti-cancer drug target. The objectives of this study were therefore (1) to explore the role of increased TBX2 levels in melanomagenesis by assessing the effect of knocking it down in melanoma cell lines, (2) to determine the mechanism by which TBX2 is upregulated by the UV-induced DNA damage pathway in melanoma cells and (3) to verify whether TBX2 is a suitable drug target by assessing the cellular sensitivity of control and TBX2-depleted cells in response to the chemotherapeutic drug cisplatin.en_ZA
dc.identifier.apacitationWansleben, S. M. (2013). <i>The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/4404en_ZA
dc.identifier.chicagocitationWansleben, Sabina Maria. <i>"The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013. http://hdl.handle.net/11427/4404en_ZA
dc.identifier.citationWansleben, S. 2013. The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Wansleben, Sabina Maria AB - T-box genes constitute an ancient family of developmentally important transcription factors that have gained prominence in cancer biology. For example, endogenous TBX2 is overexpressed in a growing list of cancers and when ectopically overexpressed it can bypass senescence and the tetraploidy checkpoints that protect against cancer. When the current study was initiated it was unclear as to whether the endogenous overexpression of TBX2 was a cause or consequence of the oncogenic process and whether it may be a suitable anti-cancer drug target. The objectives of this study were therefore (1) to explore the role of increased TBX2 levels in melanomagenesis by assessing the effect of knocking it down in melanoma cell lines, (2) to determine the mechanism by which TBX2 is upregulated by the UV-induced DNA damage pathway in melanoma cells and (3) to verify whether TBX2 is a suitable drug target by assessing the cellular sensitivity of control and TBX2-depleted cells in response to the chemotherapeutic drug cisplatin. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway TI - The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway UR - http://hdl.handle.net/11427/4404 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/4404
dc.identifier.vancouvercitationWansleben SM. The role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/4404en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherHuman Biologyen_ZA
dc.titleThe role of the transcription factor TBX2 in breast cancer and melanoma and its regulation by the UV-induced DNA damage pathway.en_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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