Spatial and temporal regulation of IL4Rα expression
dc.contributor.advisor | Brombacher, Frank | en_ZA |
dc.contributor.advisor | Horsnell, William | en_ZA |
dc.contributor.author | Smith, Elizabeth M | en_ZA |
dc.date.accessioned | 2014-07-28T14:54:09Z | |
dc.date.available | 2014-07-28T14:54:09Z | |
dc.date.issued | 2008 | en_ZA |
dc.description | Includes abstract. | |
dc.description.abstract | In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005). | en_ZA |
dc.identifier.apacitation | Smith, E. M. (2008). <i>Spatial and temporal regulation of IL4Rα expression</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/3117 | en_ZA |
dc.identifier.chicagocitation | Smith, Elizabeth M. <i>"Spatial and temporal regulation of IL4Rα expression."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2008. http://hdl.handle.net/11427/3117 | en_ZA |
dc.identifier.citation | Smith, E. 2008. Spatial and temporal regulation of IL4Rα expression. University of Cape Town. | en_ZA |
dc.identifier.ris | TY - Thesis / Dissertation AU - Smith, Elizabeth M AB - In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005). DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Spatial and temporal regulation of IL4Rα expression TI - Spatial and temporal regulation of IL4Rα expression UR - http://hdl.handle.net/11427/3117 ER - | en_ZA |
dc.identifier.uri | http://hdl.handle.net/11427/3117 | |
dc.identifier.vancouvercitation | Smith EM. Spatial and temporal regulation of IL4Rα expression. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3117 | en_ZA |
dc.language.iso | eng | en_ZA |
dc.publisher.department | Division of Immunology | en_ZA |
dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
dc.publisher.institution | University of Cape Town | |
dc.subject.other | Immunology | en_ZA |
dc.title | Spatial and temporal regulation of IL4Rα expression | en_ZA |
dc.type | Doctoral Thesis | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | PhD | en_ZA |
uct.type.filetype | Text | |
uct.type.filetype | Image | |
uct.type.publication | Research | en_ZA |
uct.type.resource | Thesis | en_ZA |
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