Spatial and temporal regulation of IL4Rα expression

dc.contributor.advisorBrombacher, Franken_ZA
dc.contributor.advisorHorsnell, Williamen_ZA
dc.contributor.authorSmith, Elizabeth Men_ZA
dc.date.accessioned2014-07-28T14:54:09Z
dc.date.available2014-07-28T14:54:09Z
dc.date.issued2008en_ZA
dc.descriptionIncludes abstract.
dc.description.abstractIn this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005).en_ZA
dc.identifier.apacitationSmith, E. M. (2008). <i>Spatial and temporal regulation of IL4Rα expression</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Immunology. Retrieved from http://hdl.handle.net/11427/3117en_ZA
dc.identifier.chicagocitationSmith, Elizabeth M. <i>"Spatial and temporal regulation of IL4Rα expression."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2008. http://hdl.handle.net/11427/3117en_ZA
dc.identifier.citationSmith, E. 2008. Spatial and temporal regulation of IL4Rα expression. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Smith, Elizabeth M AB - In this study, we generated a new mouse model, which allows both inducible and cell-specific deletion and reconstitution of IL-IL4Rα expression. This model has the potential to add a new dimension to our understanding of IL4Rα biology. This has been achieved by using the established Tet System (Goosen and Bujard, 1992) where the crossing of two complementary transgenic mouse lines enable the generation of the final double transgenic model. The first line expresses the transactivator, tTA, from the Tet-Off expression cassette driven by the Vav hemapoeitic specific promoter (Wiesner et al., 2005). DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Spatial and temporal regulation of IL4Rα expression TI - Spatial and temporal regulation of IL4Rα expression UR - http://hdl.handle.net/11427/3117 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3117
dc.identifier.vancouvercitationSmith EM. Spatial and temporal regulation of IL4Rα expression. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Immunology, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3117en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Immunologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherImmunologyen_ZA
dc.titleSpatial and temporal regulation of IL4Rα expressionen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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