Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol

Doctoral Thesis

2004

Permanent link to this Item
http://hdl.handle.net/11427/6356
Files
thesis_sci_2004_oliver_cl.pdf (18.49 MB)
Authors
Oliver, Clive Lloyd
Supervisors
Caira, Mino R
Bourne, Susan
Journal Title
Link to Journal
Journal ISSN
Volume Title
Publisher
Publisher

University of Cape Town

Department
Department of Chemistry
Faculty
Faculty of Science
License
Series
Abstract
The aim of this thesis was to prepare polymorphs, cyclodextrin inclusion complexes and salts of tulobuterol, a drug with bronchodilating properties. Polymorphic drugs are of interest to the pharmaceutical industry because of their varied physical properties, whilst the increase in aqueous solubilities of drugs by their inclusion within cyclodextrins or by salt formation is also an important pharmaceutical consideration. Two polymorphs, four cyclodextrin inclusion complexes and three salts of tulobuterol free base were successfully generated in this study.
Description

Includes bibliographical references (leaves 199-207).

Keywords
Chemistry

Reference:

Oliver, C. 2004. Polymorphs, cyclodextrin inclusion complexes and salts of the bronchodilator tulobuterol. University of Cape Town.

Collections
PhD / Doctoral