PKCε and cardioprotection : an exploration of putative mechanisms

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dc.contributor.advisorEssop, Faadielen_ZA
dc.contributor.advisorOpie, Lionel Hen_ZA
dc.contributor.authorMcCarthy, Joyen_ZA
dc.date.accessioned2014-07-29T09:07:21Z
dc.date.available2014-07-29T09:07:21Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractRecent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε. Sub-proteome analysis has identified interactions between activated PKCε and various mitochondrial proteins, which orchestrate mitochondrial homeostasis, including proteins governing mitochondrial oxidative phosphorylation, electron transfer, ion transport and control of mitochondrial permeability transition (MPT). MPT disruption is regarded as a key step in the initiation of an apoptotic cascade. However, brief pore opening may be beneficial in triggering the generation of small amounts of protective reactive oxygen species (ROS) and restoring calcium homeostasis. PKCε also interacts with adenine nucleotide translocases (ANTs), inner mitochondrial membrane proteins essential for ATP production and an integral component of the permeability transition pore. An augmented capacity to generate ATP would fundamentally enhance resilience to ischemia.en_ZA
dc.identifier.apacitationMcCarthy, J. (2006). <i>PKCε and cardioprotection : an exploration of putative mechanisms</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/3429en_ZA
dc.identifier.chicagocitationMcCarthy, Joy. <i>"PKCε and cardioprotection : an exploration of putative mechanisms."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2006. http://hdl.handle.net/11427/3429en_ZA
dc.identifier.citationMcCarthy, J. 2006. PKCε and cardioprotection : an exploration of putative mechanisms. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - McCarthy, Joy AB - Recent studies have investigated the underlying regulatory mechanisms that may explain the cardioprotective role of PKCε. Sub-proteome analysis has identified interactions between activated PKCε and various mitochondrial proteins, which orchestrate mitochondrial homeostasis, including proteins governing mitochondrial oxidative phosphorylation, electron transfer, ion transport and control of mitochondrial permeability transition (MPT). MPT disruption is regarded as a key step in the initiation of an apoptotic cascade. However, brief pore opening may be beneficial in triggering the generation of small amounts of protective reactive oxygen species (ROS) and restoring calcium homeostasis. PKCε also interacts with adenine nucleotide translocases (ANTs), inner mitochondrial membrane proteins essential for ATP production and an integral component of the permeability transition pore. An augmented capacity to generate ATP would fundamentally enhance resilience to ischemia. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - PKCε and cardioprotection : an exploration of putative mechanisms TI - PKCε and cardioprotection : an exploration of putative mechanisms UR - http://hdl.handle.net/11427/3429 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3429
dc.identifier.vancouvercitationMcCarthy J. PKCε and cardioprotection : an exploration of putative mechanisms. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3429en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedicineen_ZA
dc.titlePKCε and cardioprotection : an exploration of putative mechanismsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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