Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study

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dc.contributor.advisorFazakerley, G Ven_ZA
dc.contributor.authorKoch, Klaus Ren_ZA
dc.date.accessioned2015-03-16T10:31:07Z
dc.date.available2015-03-16T10:31:07Z
dc.date.issued1979en_ZA
dc.descriptionBibliography: p. 181-184.en_ZA
dc.description.abstractThe aqueous solution conformation of SAH and SAM has been investigated using lanthanide probes. SAH at pH 7.0 interacts normally with lanthanide aquo ions and lanthanide-EDTA complexes via coordination at the carboxyl group. The conformation of the homocysteine fragment is found to, be extended but bent back towards the adenine base. SAM does not interact with lanthanide aquo ions in the pH region 2-7. It does form complexes with lanthanide-EDTA species via an ion-pairing mechanism rather than direct coordination. In addition to lanthanide probes, 250 MHz 1H n.m.r. spectra yielded vicinal JHH coupling constants from which the ribose conformation in both SAM and SAH could be more accurately determined.en_ZA
dc.identifier.apacitationKoch, K. R. (1979). <i>Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12618en_ZA
dc.identifier.chicagocitationKoch, Klaus R. <i>"Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1979. http://hdl.handle.net/11427/12618en_ZA
dc.identifier.citationKoch, K. 1979. Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Koch, Klaus R AB - The aqueous solution conformation of SAH and SAM has been investigated using lanthanide probes. SAH at pH 7.0 interacts normally with lanthanide aquo ions and lanthanide-EDTA complexes via coordination at the carboxyl group. The conformation of the homocysteine fragment is found to, be extended but bent back towards the adenine base. SAM does not interact with lanthanide aquo ions in the pH region 2-7. It does form complexes with lanthanide-EDTA species via an ion-pairing mechanism rather than direct coordination. In addition to lanthanide probes, 250 MHz 1H n.m.r. spectra yielded vicinal JHH coupling constants from which the ribose conformation in both SAM and SAH could be more accurately determined. DA - 1979 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1979 T1 - Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study TI - Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study UR - http://hdl.handle.net/11427/12618 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12618
dc.identifier.vancouvercitationKoch KR. Heavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance study. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1979 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12618en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherInorganic Chemistryen_ZA
dc.titleHeavy metal interactions with nucleic acid derivatives : a nuclear magnetic resonance studyen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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