Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B

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dc.contributor.advisorCoyne, Vernonen_ZA
dc.contributor.authorSchroeder, Irmagard Cherèen_ZA
dc.date.accessioned2016-01-02T04:39:17Z
dc.date.available2016-01-02T04:39:17Z
dc.date.issued1998en_ZA
dc.descriptionBibliography: p. 155-177.en_ZA
dc.description.abstractV. cholerae 569B is a bacterium infamous for its role as the causative agent of the diarrhoeal disease cholera. Although the bacterium occurs naturally in brackish waters and estuaries, cholera outbreaks are closely linked to specific environmental conditions. For example, most outbreaks occur during the summer months when the bacterium experiences an increase in water temperature, play a role in activating virulence in V. cholerae 569B, the exact mechanism remains to be elucidated. Previously it was observed that when V. cholerae is exposed to elevated temperature and salinity, the bacterium initiates the synthesis of a brown-black pigment known as melanin. The function of the pigment and the genes involved in its synthesis was unknown. We therefore set out to determine the function of pigmentation in V. cholerae 569B, since pigmentation could significantly enhance the survival of the bacterium during adverse conditions and therefore aid in the persistence of the organism in the environment.en_ZA
dc.identifier.apacitationSchroeder, I. C. (1998). <i>Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/16110en_ZA
dc.identifier.chicagocitationSchroeder, Irmagard Cherè. <i>"Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 1998. http://hdl.handle.net/11427/16110en_ZA
dc.identifier.citationSchroeder, I. 1998. Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Schroeder, Irmagard Cherè AB - V. cholerae 569B is a bacterium infamous for its role as the causative agent of the diarrhoeal disease cholera. Although the bacterium occurs naturally in brackish waters and estuaries, cholera outbreaks are closely linked to specific environmental conditions. For example, most outbreaks occur during the summer months when the bacterium experiences an increase in water temperature, play a role in activating virulence in V. cholerae 569B, the exact mechanism remains to be elucidated. Previously it was observed that when V. cholerae is exposed to elevated temperature and salinity, the bacterium initiates the synthesis of a brown-black pigment known as melanin. The function of the pigment and the genes involved in its synthesis was unknown. We therefore set out to determine the function of pigmentation in V. cholerae 569B, since pigmentation could significantly enhance the survival of the bacterium during adverse conditions and therefore aid in the persistence of the organism in the environment. DA - 1998 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1998 T1 - Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B TI - Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B UR - http://hdl.handle.net/11427/16110 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16110
dc.identifier.vancouvercitationSchroeder IC. Molecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569B. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 1998 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/16110en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMicrobiologyen_ZA
dc.titleMolecular and functional characterization of the melanin biosynthetic genes from Vibrio cholerae 569Ben_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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