Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study

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dc.contributor.authorJohnson, Leigh F
dc.contributor.authorMay, Margaret T
dc.contributor.authorCornell, Morna
dc.contributor.authorBoulle, Andrew
dc.contributor.authorEgger, Matthias
dc.contributor.authorDavies, Mary-Ann
dc.date.accessioned2021-10-08T07:15:51Z
dc.date.available2021-10-08T07:15:51Z
dc.date.issued2017
dc.description.abstractSubstantial reductions in adult mortality have been observed in South Africa since the mid-2000s, but there has been no formal evaluation of how much of this decline is attributable to the scale-up of antiretroviral treatment (ART), as previous models have not been calibrated to vital registration data. We developed a deterministic mathematical model to simulate the mortality trends that would have been expected in the absence of ART, and with earlier introduction of ART.
dc.identifier.apacitationJohnson, L. F., May, M. T., Cornell, M., Boulle, A., Egger, M., & Davies, M. (2017). Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study. <i>PLoS Medicine</i>, 14(12), e1002468 - 177. http://hdl.handle.net/11427/34712en_ZA
dc.identifier.chicagocitationJohnson, Leigh F, Margaret T May, Morna Cornell, Andrew Boulle, Matthias Egger, and Mary-Ann Davies "Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study." <i>PLoS Medicine</i> 14, 12. (2017): e1002468 - 177. http://hdl.handle.net/11427/34712en_ZA
dc.identifier.citationJohnson, L.F., May, M.T., Cornell, M., Boulle, A., Egger, M. & Davies, M. 2017. Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study. <i>PLoS Medicine.</i> 14(12):e1002468 - 177. http://hdl.handle.net/11427/34712en_ZA
dc.identifier.issn1549-1277
dc.identifier.issn1549-1676
dc.identifier.ris TY - Journal Article AU - Johnson, Leigh F AU - May, Margaret T AU - Cornell, Morna AU - Boulle, Andrew AU - Egger, Matthias AU - Davies, Mary-Ann AB - Substantial reductions in adult mortality have been observed in South Africa since the mid-2000s, but there has been no formal evaluation of how much of this decline is attributable to the scale-up of antiretroviral treatment (ART), as previous models have not been calibrated to vital registration data. We developed a deterministic mathematical model to simulate the mortality trends that would have been expected in the absence of ART, and with earlier introduction of ART. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 12 J1 - PLoS Medicine LK - https://open.uct.ac.za PY - 2017 SM - 1549-1277 SM - 1549-1676 T1 - Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study TI - Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study UR - http://hdl.handle.net/11427/34712 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34712
dc.identifier.vancouvercitationJohnson LF, May MT, Cornell M, Boulle A, Egger M, Davies M. Estimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study. PLoS Medicine. 2017;14(12):e1002468 - 177. http://hdl.handle.net/11427/34712.en_ZA
dc.language.isoeng
dc.publisher.departmentCentre for Infectious Disease Epidemiology and Research
dc.publisher.facultyFaculty of Health Sciences
dc.sourcePLoS Medicine
dc.source.journalissue12
dc.source.journalvolume14
dc.source.paginatione1002468 - 177
dc.source.urihttps://dx.doi.org/10.1371/journal.pmed.1002468
dc.subject.otherDeath rates
dc.subject.otherHIV
dc.subject.otherHIV epidemiology
dc.subject.otherAntiretroviral therapy
dc.subject.otherSouth Africa
dc.subject.otherHIV diagnosis and management
dc.subject.otherAIDS
dc.subject.otherTuberculosis
dc.titleEstimating the impact of antiretroviral treatment on adult mortality trends in South Africa: A mathematical modelling study
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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