Development of new bioorganometallic metallodendrimers as in vitro anticancer agents

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dc.contributor.advisorSmith, Gregory Sen_ZA
dc.contributor.authorGovender, Preshendrenen_ZA
dc.date.accessioned2014-10-21T14:23:13Z
dc.date.available2014-10-21T14:23:13Z
dc.date.issued2014en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractThe clinical success of cisplatin and its derivatives for the treatment of different cancers has had a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study of bioorganometallic complexes as potential therapeutic agents may eventually lead to the identification of new drug candidates. The purpose of this study was to synthesize and characterize a series of polynuclear transition-metal-containing complexes based on a (poly)propyleneimine dendritic scaffold, and investigate the in vitro antiproliferative activity of these complexes.en_ZA
dc.identifier.apacitationGovender, P. (2014). <i>Development of new bioorganometallic metallodendrimers as in vitro anticancer agents</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/8720en_ZA
dc.identifier.chicagocitationGovender, Preshendren. <i>"Development of new bioorganometallic metallodendrimers as in vitro anticancer agents."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2014. http://hdl.handle.net/11427/8720en_ZA
dc.identifier.citationGovender, P. 2014. Development of new bioorganometallic metallodendrimers as in vitro anticancer agents. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Govender, Preshendren AB - The clinical success of cisplatin and its derivatives for the treatment of different cancers has had a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study of bioorganometallic complexes as potential therapeutic agents may eventually lead to the identification of new drug candidates. The purpose of this study was to synthesize and characterize a series of polynuclear transition-metal-containing complexes based on a (poly)propyleneimine dendritic scaffold, and investigate the in vitro antiproliferative activity of these complexes. DA - 2014 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Development of new bioorganometallic metallodendrimers as in vitro anticancer agents TI - Development of new bioorganometallic metallodendrimers as in vitro anticancer agents UR - http://hdl.handle.net/11427/8720 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/8720
dc.identifier.vancouvercitationGovender P. Development of new bioorganometallic metallodendrimers as in vitro anticancer agents. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2014 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/8720en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Laboratory Sciencesen_ZA
dc.titleDevelopment of new bioorganometallic metallodendrimers as in vitro anticancer agentsen_ZA
dc.typeDoctoral Thesis
dc.type.qualificationlevelDoctoral
dc.type.qualificationnamePhDen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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