Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
Doctoral Thesis
2011
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University of Cape Town
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Abstract
The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
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Mbele, P. 2011. Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity. University of Cape Town.